The mechanistic target of rapamycin complex 1 (mTORC1) is an essential regulator of cell
growth and metabolism through the modulation of protein and lipid synthesis, lysosome …

The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular
metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and …

The class I phosphoinositide 3-kinase (PI3K)–mechanistic target of rapamycin (mTOR)
complex 1 (mTORC1) signaling network directs cellular metabolism and growth. Activation …

Since the discovery that rapamycin, a small molecule inhibitor of the protein kinase mTOR
(mechanistic target of rapamycin), can extend the lifespan of model organisms including …

TOR (target of rapamycin), an evolutionarily-conserved serine/threonine kinase, acts as a
central regulator of cell growth, proliferation and survival in response to nutritional status …

The protein kinase mechanistic target of rapamycin (mTOR) functions as a central regulator
of metabolism, integrating diverse nutritional and hormonal cues to control anabolic …

Coordinating cell growth with nutrient availability is critical for cell survival. The evolutionarily
conserved TOR (target of rapamycin) controls cell growth in response to nutrients, in …

Autophagy, which is tightly regulated by a series of autophagy-related genes (ATGs), is a
vital intracellular homeostatic process through which defective proteins and organelles are …

The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of metabolic
and nutrient cues that integrates environmental inputs into downstream signaling pathways …

Abstract mTORC1 promotes cell growth and is therefore inactivated upon unfavourable
growth conditions. Signalling pathways downstream of most cellular stresses converge on …