Mental disorder classification provides a definitional framework that underlies applied
clinical and research efforts to understand, assess, predict, prevent and ameliorate the …

The format of the original Hamilton Rating Scale for Depression (HAM-D) was unstructured:
only general instructions were provided for rating individual items. Over the years, a number …

Background Treatment-resistant major depressive disorder is common; repetitive
transcranial magnetic stimulation (rTMS) by use of high-frequency (10 Hz) left-side …

Bipolar disorder is heterogeneous in phenomenology, illness trajectory, and response to
treatment. Despite evidence for the efficacy of multimodality interventions, the majority of …

Abstract Background Prefrontal Transcranial Magnetic Stimulation (TMS) therapy repeated
daily over 4–6 weeks (20–30 sessions) is US Food and Drug Administration (FDA) approved …

Background Comorbidity between depressive and anxiety disorders is common. A
hypothesis of the network perspective on psychopathology is that comorbidity arises due to …

Background Psychiatric disorders are highly heterogeneous, defined based on symptoms
with little connection to potential underlying biological mechanisms. A possible approach to …

Background: The best treatment options for binge-eating disorder are unclear. Purpose: To
summarize evidence about the benefits and harms of psychological and pharmacologic …

There has been a marked increase of network studies of Major Depressive Disorder (MDD).
Despite rapidly growing contributions, their findings have yet to be systematically …

Background The N-methyl-D-aspartate glutamate receptor antagonist ketamine, delivered
via an intravenous route, has shown rapid antidepressant effects in patients with treatment …