A review of 3D polymeric scaffolds for bone tissue engineering: principles, fabrication techniques, immunomodulatory roles, and challenges

AG Abdelaziz, H Nageh, SM Abdo, MS Abdalla… - Bioengineering, 2023 - mdpi.com
Over the last few years, biopolymers have attracted great interest in tissue engineering and
regenerative medicine due to the great diversity of their chemical, mechanical, and physical …

[HTML][HTML] Recent advances in defined hydrogels in organoid research

Z Gan, X Qin, H Liu, J Liu, J Qin - Bioactive Materials, 2023 - Elsevier
Organoids are in vitro model systems that mimic the complexity of organs with multicellular
structures and functions, which provide great potential for biomedical and tissue …

[HTML][HTML] Cell–scaffold interactions in tissue engineering for oral and craniofacial reconstruction

F Wang, X Cai, Y Shen, L Meng - Bioactive Materials, 2023 - Elsevier
Tissue engineering (TE) is critical in oral and craniofacial reconstruction. One of the most
popular topics on the biomaterial-based tissue regeneration process may be the interaction …

Stiff extracellular matrix drives the differentiation of mesenchymal stem cells toward osteogenesis by the multiscale 3D genome reorganization

J Na, C Tai, Z Wang, Z Yang, X Chen, J Zhang… - Biomaterials, 2025 - Elsevier
Extracellular matrix (ECM) stiffness is a major driver of stem cell fate. However, the
involvement of the three-dimensional (3D) genomic reorganization in response to ECM …

Hydrogels and bioprinting in bone tissue engineering: creating artificial stem‐cell niches for in vitro models

FK Lewns, O Tsigkou, LR Cox, RD Wildman… - Advanced …, 2023 - Wiley Online Library
Advances in bioprinting have enabled the fabrication of complex tissue constructs with high
speed and resolution. However, there remains significant structural and biological …

[HTML][HTML] Integrating physicomechanical and biological strategies for BTE: biomaterials-induced osteogenic differentiation of MSCs

H Shi, K Zhou, M Wang, N Wang, Y Song, W Xiong… - Theranostics, 2023 - ncbi.nlm.nih.gov
Large bone defects are a major global health concern. Bone tissue engineering (BTE) is the
most promising alternative to avoid the drawbacks of autograft and allograft bone …

Biomaterials regulates BMSCs differentiation via mechanical microenvironment

Q Gao, J Liu, M Wang, X Liu, Y Jiang, J Su - Biomaterials Advances, 2024 - Elsevier
Bone mesenchymal stem cells (BMSCs) are crucial for bone tissue regeneration, the
mechanical microenvironment of hard tissues, including bone and teeth, significantly affects …

Bone tissue engineering using osteogenic cells: from the bench to the clinical application

JA Shibli, BE Nagay, LJ Suárez… - … Engineering Part C …, 2022 - liebertpub.com
The use of tissue engineering to restore and to build new bone tissue is under active
research at present. The following review summarizes the latest studies and clinical trials …

[HTML][HTML] Biofabricating the vascular tree in engineered bone tissue

L de Silva, PN Bernal, AJW Rosenberg, J Malda… - Acta Biomaterialia, 2023 - Elsevier
The development of tissue engineering strategies for treatment of large bone defects has
become increasingly relevant, given the growing demand for bone substitutes. Native bone …

Rheological characterization of cell-laden alginate-gelatin hydrogels for 3D biofabrication

T Gregory, P Benhal, A Scutte, D Quashie Jr… - Journal of the …, 2022 - Elsevier
Biofabrication of tissue models that closely mimic the tumor microenvironment is necessary
for high-throughput anticancer therapeutics. Extrusion-based bioprinting of heterogeneous …