Investigation of Siderophore–Platinum (IV) Conjugates Reveals Differing Antibacterial Activity and DNA Damage Depending on the Platinum Cargo
C Guo, KKA Wang, EM Nolan - ACS Infectious Diseases, 2024 - ACS Publications
The growing threat of bacterial infections coupled with the dwindling arsenal of effective
antibiotics has heightened the urgency for innovative strategies to combat bacterial …
antibiotics has heightened the urgency for innovative strategies to combat bacterial …
Developing novel antimicrobials by combining cancer chemotherapeutics with bacterial DNA repair inhibitors
Cancer chemotherapeutics kill rapidly dividing cells, which includes cells of the immune
system. The resulting neutropenia predisposes patients to infection, which delays treatment …
system. The resulting neutropenia predisposes patients to infection, which delays treatment …
Identification of a novel DNA repair inhibitor using an in silico driven approach shows effective combinatorial activity with genotoxic agents against multidrug‐resistant …
Increasing antimicrobial drug resistance represents a global existential threat. Infection is a
particular problem in immunocompromised individuals, such as patients undergoing cancer …
particular problem in immunocompromised individuals, such as patients undergoing cancer …
Antibiofilm formation activity of lupinifolin isolated from Derris reticulata stems against Enterococcus faecalis
P Pulbutr, K Seelakot… - Journal of Herbmed …, 2024 - herbmedpharmacol.com
Introduction: The biofilm formation capability of Enterococcus faecalis is one of the key
virulence factors contributing to its multidrug resistance and therapeutic challenges …
virulence factors contributing to its multidrug resistance and therapeutic challenges …
Siderophore-Based Drug Repurposing of Platinum Anticancer Agents as Targeted Antibiotics and Investigation of Pt-Induced DNA Damage in Gram-Negative …
C Guo - 2023 - dspace.mit.edu
Bacterial infections are a growing threat to human health. This crisis has been exacerbated
by the overuse of broad-spectrum antibiotics, resulting in adverse consequences such as …
by the overuse of broad-spectrum antibiotics, resulting in adverse consequences such as …
Combining cancer chemotherapeutics with bacterial DNA repair inhibitors to develop novel antimicrobials
Cancer chemotherapeutics kill rapidly dividing cells, which includes cells of the immune
system. The resulting neutropenia predisposes patients to infection, which delays treatment …
system. The resulting neutropenia predisposes patients to infection, which delays treatment …