Lipids and lipid derivatives for RNA delivery
RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …
diseases through various mechanisms including knockdown of pathological genes …
From influenza to COVID-19: Lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases
Vaccination represents the best line of defense against infectious diseases and is crucial in
curtailing pandemic spread of emerging pathogens to which a population has limited …
curtailing pandemic spread of emerging pathogens to which a population has limited …
Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA
Endosomal sequestration of lipid-based nanoparticles (LNPs) remains a formidable barrier
to delivery. Herein, structure-activity analysis of cholesterol analogues reveals that …
to delivery. Herein, structure-activity analysis of cholesterol analogues reveals that …
Advances in lipid nanoparticles for mRNA-based cancer immunotherapy
Over the past decade, messenger RNA (mRNA) has emerged as potent and flexible platform
for the development of novel effective cancer immunotherapies. Advances in non-viral gene …
for the development of novel effective cancer immunotherapies. Advances in non-viral gene …
Lipid nanoparticles as delivery systems for RNA-based vaccines
BN Aldosari, IM Alfagih, AS Almurshedi - Pharmaceutics, 2021 - mdpi.com
There has been increased interest in the development of RNA-based vaccines for protection
against various infectious diseases and also for cancer immunotherapies. Rapid and cost …
against various infectious diseases and also for cancer immunotherapies. Rapid and cost …
Three decades of messenger RNA vaccine development
R Verbeke, I Lentacker, SC De Smedt, H Dewitte - Nano Today, 2019 - Elsevier
In the early nineties, pioneering steps were taken in the use of mRNA as a therapeutic tool
for vaccination. In the following decades, an improved understanding of the mRNA …
for vaccination. In the following decades, an improved understanding of the mRNA …
Barriers and strategies of cationic liposomes for cancer gene therapy
C Liu, L Zhang, W Zhu, R Guo, H Sun, X Chen… - … Therapy Methods & …, 2020 - cell.com
Cationic liposomes (CLs) have been regarded as the most promising gene delivery vectors
for decades with the advantages of excellent biodegradability, biocompatibility, and high …
for decades with the advantages of excellent biodegradability, biocompatibility, and high …
Brief update on endocytosis of nanomedicines
The complexity of nanoscale interactions between biomaterials and cells has limited the
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …
Effect of polyethyleneglycol (PEG) chain length on the bio–nano-interactions between PEGylated lipid nanoparticles and biological fluids: from nanostructure to uptake …
D Pozzi, V Colapicchioni, G Caracciolo, S Piovesana… - Nanoscale, 2014 - pubs.rsc.org
When nanoparticles (NPs) enter a physiological environment, medium components compete
for binding to the NP surface leading to formation of a rich protein shell known as the …
for binding to the NP surface leading to formation of a rich protein shell known as the …
Nanomedicine-based approaches for mRNA delivery
Messenger RNA (mRNA) has immense potential for developing a wide range of therapies,
including immunotherapy and protein replacement. As mRNA presents no risk of integration …
including immunotherapy and protein replacement. As mRNA presents no risk of integration …