The amyloid-β oligomer hypothesis: beginning of the third decade
The amyloid-β oligomer (AβO) hypothesis was introduced in 1998. It proposed that the brain
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …
Old drugs as new treatments for neurodegenerative diseases
F Durães, M Pinto, E Sousa - Pharmaceuticals, 2018 - mdpi.com
Neurodegenerative diseases are increasing in number, given that the general global
population is becoming older. They manifest themselves through mechanisms that are not …
population is becoming older. They manifest themselves through mechanisms that are not …
Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)
FX Theillet, A Binolfi, T Frembgen-Kesner… - Chemical …, 2014 - ACS Publications
It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …
Features and outcomes of drugs for combination therapy as multi-targets strategy to combat Alzheimer's disease
AK Sahoo, J Dandapat, UC Dash, S Kanhar - Journal of …, 2018 - Elsevier
Ethnopharmacological relevance Alzheimer's disease (AD), a deleterious
neurodegenerative disorder that impairs memory, cognitive functions and may lead to …
neurodegenerative disorder that impairs memory, cognitive functions and may lead to …
Modeling human diseases in Caenorhabditis elegans
M Markaki, N Tavernarakis - Biotechnology journal, 2010 - Wiley Online Library
Genes linked to human diseases often function in evolutionarily conserved pathways, which
can be readily dissected in simple model organisms. Because of its short lifespan and well …
can be readily dissected in simple model organisms. Because of its short lifespan and well …
Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases
Age-associated neurodegenerative disorders such as Alzheimer's disease are a major
public health challenge, due to the demographic increase in the proportion of older …
public health challenge, due to the demographic increase in the proportion of older …
Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity
C Fatouros, GJ Pir, J Biernat… - Human molecular …, 2012 - academic.oup.com
Increased Tau protein amyloidogenicity has been causatively implicated in several
neurodegenerative diseases, collectively called tauopathies. In pathological conditions, Tau …
neurodegenerative diseases, collectively called tauopathies. In pathological conditions, Tau …
A Caenorhabditis elegans–based assay recognizes immunoglobulin light chains causing heart amyloidosis
L Diomede, P Rognoni, F Lavatelli… - Blood, The Journal …, 2014 - ashpublications.org
Poor prognosis and limited therapeutic options characterize immunoglobulin light-chain (AL)
amyloidosis with major heart involvement. Reliable experimental models are needed to …
amyloidosis with major heart involvement. Reliable experimental models are needed to …
Oleuropein Aglycone Protects Transgenic C. elegans Strains Expressing Aβ42 by Reducing Plaque Load and Motor Deficit
The presence of amyloid aggregates of the 42 amino acid peptide of amyloid beta (Aβ42) in
the brain is the characteristic feature of Alzheimer's disease (AD). Amyloid beta (Aβ …
the brain is the characteristic feature of Alzheimer's disease (AD). Amyloid beta (Aβ …
Modeling neurodegenerative diseases in Caenorhabditis elegans
J Li, W Le - Experimental neurology, 2013 - Elsevier
Neurodegenerative diseases which include Alzheimer's disease (AD), Parkinson's disease
(PD), amyotrophic lateral sclerosis (ALS), Huntington disease (HD), and others are …
(PD), amyotrophic lateral sclerosis (ALS), Huntington disease (HD), and others are …