Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Recently, a rhodopsin protein mimic was constructed by combining mutants of the cellular
retinoic acid binding protein II (CRABPII) with an all-trans retinal chromophore. Here, we …

Cellular retinoic acid binding protein 2 (CRABP2) transports retinoic acid from the cytoplasm
to the nucleus where it then transfers its cargo to retinoic acid receptor-containing …

A detailed understanding of the interactions between small-molecule ligands and their
proposed binding targets is of the utmost importance for modern drug-development …

A reengineered human cellular retinol binding protein II (hCRBPII), a 15‐kDa protein
belonging to the intracellular lipid binding protein (iLBP) family, generates a highly …

The conformational profiles of unbound all-trans and 9-cis retinoic acid (RA) have been
determined using classical and quantum mechanical calculations. Sixty-six all-trans-RA …

Rhodopsins are the sensor molecules responsible for visual perception in all sighted
organisms.[1] They all consist of a protein, opsin, bound to a retinoid polyene, most typically …

Retinoic acid (RA) is a vitamin A derivative, which modifies the appearance of fine wrinkles
and roughness of facial skin and treats acne and activates gene transcription by binding to …

Mutants of cellular retinoic acid‐binding protein II (CRABPII), engineered to bind all‐trans‐
retinal as an iminium species, demonstrate photochromism upon irradiation with light at …

The binding of retinoic acid to mutants of Cellular Retinoic Acid Binding Protein II (CRABPII)
was evaluated to better understand the importance of the direct protein/ligand interactions …