A review: Synthetic approaches and biological applications of triazole derivatives

U Salma, S Ahmad, MZ Alam, SA Khan - Journal of Molecular Structure, 2024 - Elsevier
The triazole scaffold is a key element in heterocyclic chemistry, giving a fundamental
building block in organic, medicinal chemistry, and material science. Triazole composed of a …

Heterocyclic compounds as a magic bullet for diabetes mellitus: a review

U Farwa, MA Raza - RSC advances, 2022 - pubs.rsc.org
Diabetes mellitus (DM) is a major metabolic disorder due to hyperglycemia, which is
increasing all over the world. From the last two decades, the use of synthetic agents has …

Novel 2-acetamido-2-ylidene-4-imidazole derivatives (El-Saghier reaction): Green synthesis, biological assessment, and molecular docking

AM El-Saghier, A Abdou, MAA Mohamed… - ACS …, 2023 - ACS Publications
El-Saghier reaction is the novel, general, and green reaction of various amines with ethyl
cyanoacetate and ethyl glycinate hydrochloride. A new series of imidazolidin-4-ones and bis …

An operationally simple, one‐pot, convenient synthesis, and in vitro anti‐inflammatory activity of some new spirotriazolotriazine derivatives

AM El‐Saghier, SS Enaili, A Abdou… - Journal of …, 2024 - Wiley Online Library
The wide biological actions of triazolotriazine hybrids, benzene‐sulfonamide derivatives,
exhibit a good chance of displaying in vitro anti‐inflammatory effects. An operationally …

An efficient eco-friendly, simple, and green synthesis of some new spiro-N-(4-sulfamoyl-phenyl)-1, 3, 4-thiadiazole-2-carboxamide derivatives as potential inhibitors of …

AM El-Saghier, SS Enaili, A Abdou, AM Kadry - Molecular Diversity, 2024 - Springer
Introduction The coronavirus disease 2019 (COVID-19) pandemic has caused a global
health crisis. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a …

Ultrasound-assisted green synthesis of triazole-based azomethine/thiazolidin-4-one hybrid inhibitors for cancer therapy through targeting dysregulation signatures of …

AH Abdelmonsef, AM El-Saghier… - Green Chemistry Letters …, 2023 - Taylor & Francis
The overexpression of Rab proteins was linked to cancer development, making this family of
proteins an attractive drug target for the identification of novel inhibitors against tumor …

Chalcones: Versatile intermediates in heterocyclic synthesis

YN Nayak, SL Gaonkar, M Sabu - Journal of Heterocyclic …, 2023 - Wiley Online Library
Chalcones are a fascinating and well‐studied group of organic molecules. Synthesis of
chalcones has been one of the essential areas of organic synthesis over the last few …

New 4-(arylidene) amino-1, 2, 4-traizole-5-thiol derivatives and their acyclo thioglycosides as α-glucosidase and α-amylase inhibitors: Design, synthesis, and …

H El Sayed, MMK Farahat, LF Awad, M Balbaa… - Journal of Molecular …, 2022 - Elsevier
Abstract A series of 1, 2, 4-triazole Schiffs bases 3-9 and their respective acyclo
thioglycosides 10-15 based α-glucosidase and α-amylase inhibitors were synthesized under …

Chromenol derivatives as novel antifungal agents: Synthesis, in silico and in vitro evaluation

M Zveaghintseva, E Stingaci, S Pogrebnoi… - Molecules, 2021 - mdpi.com
Herein we report the synthesis of some new 1 H-1, 2, 4-triazole functionalized chromenols
(3a–3n) via tandem reactions of 1-(alkyl/aryl)-2-(1 H-1, 2, 4-triazole-1-yl) with salicylic …

Lemon juice: a versatile biocatalyst and green solvent in organic transformations

BB Shaik, P Seboletswe, SB Mohite, NK Katari… - …, 2022 - Wiley Online Library
Green chemistry is the basis for fast‐growing, eco‐friendly, alternative sustainable
technologies for the development of chemical products without the use or generation of …