Adenosine monophosphate-activated protein kinase (AMPK) is in charge of numerous
catabolic and anabolic signaling pathways to sustain appropriate intracellular adenosine …

Evidence for the physiological functions of UCP2 and UCP3 is critically reviewed. They do
not mediate adaptive thermogenesis, but they may be significantly thermogenic under …

Oxidative stress and cardiomyocyte apoptosis are involved in the pathogenesis of
doxorubicin (DOX)-induced cardiotoxicity. Matrine is well-known for its powerful anti-oxidant …

This review focuses on the emerging evidence that reactive oxygen species (ROS) derived
from glucose metabolism, such as H2O2, act as metabolic signaling molecules for glucose …

The physiological functions of the mitochondrial uncoupling proteins (UCP2 and UCP3) are
still under debate. There is, however, ample evidence to indicate that, in contrast to UCP1 …

Acetaminophen (APAP) overdose results in acute liver failure and has limited treatment
options. Previous studies show that stimulating liver regeneration is critical for survival after …

Distinct mechanisms are believed to regulate growth of the liver during fetal development
and after injury in adults, because the former relies on progenitors and the latter generally …

Obesity is a complex disease caused by the interaction of a myriad of genetic, dietary,
lifestyle and environmental factors, which favors a chronic positive energy balance, leading …

Carbon monoxide (CO), one of the end products of heme oxygenase activity, inhibits smooth
muscle proliferation by decreasing ERK1/2 phosphorylation andcyclin D1 expression, a …

The accumulation of oxidative damage to DNA and other biomolecules plays an important
role in the etiology of aging and age-related diseases such as type 2 diabetes mellitus …