Inflammatory bowel diseases (IBD) are chronic relapsing idiopathic inflammatory conditions
affecting the gastrointestinal tract. They are mainly represented by two forms, ulcerative …

The brain has a very high oxygen consumption rate and is particularly sensitive to oxidative
stress. It is also the last organ to suffer from a loss of selenium (Se) in case of deficiency. Se …

Direct reprogramming of retinal Müller glia is a promising avenue for replacing
photoreceptors and retinal ganglion cells lost to retinal dystrophies. However, questions …

Age-related macular degeneration (AMD) is a leading cause of blindness, affecting 200
million people worldwide. To identify genes that could be targeted for treatment, we created …

The increasing life expectancy has led to a higher incidence of age-related
neurodegenerative conditions. Within this framework, neuroinflammation emerges as a …

Retinoic acid (RA), the derivative of vitamin A/retinol, is a signaling molecule with important
implications in health and disease. It is a well-known developmental morphogen that …

Unlike mammals, some nonmammalian species recruit Müller glia for retinal regeneration
after injury. Identifying the underlying mechanisms may help to foresee regenerative …

Background Inflammasome activation and the subsequent release of pro-inflammatory
cytokines including Interleukin 1β (IL-1β) have been widely reported to contribute to the …

Müller glia are a cellular source for neuronal regeneration in vertebrate retinas. However,
the capacity for retinal regeneration varies widely across species. Understanding the …

Glaucoma affects approximately 80 million individuals worldwide, a condition for which
current treatment options are inadequate. The primary risk factor for glaucoma is elevated …