Matrix metalloproteinases (MMPs) and related enzymes (ADAMs, ADAMTS) and their
inhibitors control matrix turnover and function. Recent advances in our understanding of …

Introduction Aseptic loosening is the most common cause of total hip arthroplasty (THA)
failure and revision surgery. Genetic polymorphisms could be determinant factors for implant …

Matrix metalloproteinases (MMPs) are a family of zinc (Zn)-dependent endopeptidases that
are collectively capable of cleaving virtually all extracellular matrix (ECM) substrates and …

Objective Dental implants consist in the treatment of choice to replace tooth loss. The
knowledge that implant loss tends to cluster in subsets of individuals may indicate that host …

Gallium oxide has known beneficial osteo-integrative properties. This may have importance
for improving the osteointegration of orthopedic implants. At high concentrations gallium is …

Background Overwhelming evidence supports the concept that wear particles are the
primary initiator of aseptic loosening of orthopaedic implants. It is likely, however, that other …

Periprosthetic joint infection (PJI) is a multifactorial disease, and the risk of contracting
infection is determined by the complex interplays between environmental and host-related …

Osteoarthritis is the most common form of arthritis with still unknown pathogenic etiology and
considerable contribution of genetic factors. One of the mechanisms of cartilage degradation …

Introduction: Patient-specific instrumentation (PSI) has been developed for total ankle
arthroplasty (TAA), with proven benefits. One concern regarding PSI is the need for more soft …

Background Total joint arthroplasty (TJA) is one of the most frequent surgical procedures
performed in modern hospitals, and aseptic loosening is the most common indication for …