Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have
significant cardiovascular morbidity and mortality that is in part due to the development of …

Arterial stiffness is a growing epidemic associated with increased risk of cardiovascular
events, dementia, and death. Decreased compliance of the central vasculature alters arterial …

The link between vascular calcification (VC) and increased mortality is now well established.
Over time, as clinical importance of this phenomenon has begun to be fully considered …

Background—Vascular calcification is associated with increased morbidity and mortality in
stage V chronic kidney disease, yet its early pathogenesis and initiating mechanisms in vivo …

The International Society of Nephrology has adopted a proactive approach to defining the
current state of kidney care and unmet needs through a multifaceted Closing the Gaps …

Despite the availability of global and regional guidelines to curtail the adverse clinical
outcomes associated with chronic kidney disease–mineral and bone disorder (CKD-MBD) …

Background: Patients with end-stage renal disease on maintenance dialysis therapy have a
high prevalence of cardiovascular risk factors and cardiovascular disease (CVD). A similar …

Coronary artery calcification is more prevalent in dialysis patients than in patients without
kidney disease and this is associated with high serum phosphorus. In this study, we …

Arterial stiffness is an age-related disorder. In the medial layer of arteries, mechanical
fracture due to fatigue failure for the pulsatile wall strain causes medial degeneration …

Solid tumors house an assortment of complex and dynamically changing microenvironments
in which signaling events between multiple cell types are known to play a critical role in …