Tumor-induced osteomalacia (TIO) is an ultrarare paraneoplastic syndrome due to
overproduction of fibroblast growth factor 23 (FGF23), with profound effects on patient …

The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

The bone-derived hormone fibroblast growth factor 23 (FGF23) functions in concert with
parathyroid hormone (PTH) and the active vitamin D metabolite, 1, 25 (OH) 2 vitamin D (1 …

Bone regulates its mass and quality in response to diverse mechanical, hormonal, and local
signals. The bone anabolic or catabolic responses to these signals are often received by …

Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that can lead to ankylosis
by secondary ossification of inflammatory lesions, with progressive disability and a …

Osteoporosis is a common bone metabolic disease in postmenopausal women, diabetic
patients and obese patients and is characterized by an imbalance in bone formation and …

Since phosphorus is a component of hydroxyapatite, its prolonged deprivation affects bone
mineralization. Fibroblast growth factor 23 (FGF23) is essential for maintaining phosphate …

With exercise, muscle and bone produce factors with beneficial effects on brain, fat, and
other organs. Exercise in mice increased fibroblast growth factor 23 (FGF23), urine …

The Notch pathway is an evolutionarily preserved signaling pathway involved in a variety of
vital cell functions. Additionally, it is one of the key regulators of inflammation, and controls …

X-linked hypophosphatemia (XLH) is the most common hereditary form of rickets and
deficiency of renal tubular phosphate transport in humans. XLH is caused by the inactivation …