Potentiating‐antibiotic activity and absorption, distribution, metabolism, excretion and toxicity properties (ADMET) analysis of synthetic thiadiazines against multi‐drug …
ACJ de Araújo, PR Freitas, IM Araújo… - Fundamental & …, 2024 - Wiley Online Library
Background Thiadiazines are heterocyclic compounds that contain two nitrogen atoms and
one sulfur atom in their structure. These synthetic molecules have several relevant …
one sulfur atom in their structure. These synthetic molecules have several relevant …
Synthesis, vibrational analysis, thermal analysis, quantum-chemical calculation, molecular docking and dynamics, DMPK and evaluation of the antichagasic potential …
JVS Nunes, EM Marinho, CHA Roberto… - Journal of Molecular …, 2024 - Elsevier
Chagas disease affects 7 million people worldwide and is endemic in 20 Latin American
countries. It is estimated to cause about 14,000 deaths annually and more than 75 million …
countries. It is estimated to cause about 14,000 deaths annually and more than 75 million …
Antichagasic evaluation, molecular docking and ADMET properties of the chalcone (2E)-3-(2-fluorophenyl)-1-(2-hydroxy- 3,4,6-trimethoxyphenyl)prop-2-en-1-one …
CHL Cavalcante, FWQ Almeida-Neto… - Journal of …, 2023 - Taylor & Francis
Characterized as a neglected disease, Chagas disease is an infection that, in the current
scenario, affects about 8 million people per year, with a higher incidence in underdeveloped …
scenario, affects about 8 million people per year, with a higher incidence in underdeveloped …
Elongation on aliphatic chain improves selectivity of 2-hydroxy-3,4,6-trimethoxyphenyl chalcone on Trypanosoma cruzi
LR Ribeiro, EP Magalhães… - Future Medicinal …, 2024 - Taylor & Francis
Aim: Our objective was to investigate the trypanocidal effect of the chalcone (2 E, 4 E)-1-(2-
hydroxy-3, 4, 6-trimethoxyphenyl)-5-phenylpenta-2, 4-dien-1-one (CPNC). Material & …
hydroxy-3, 4, 6-trimethoxyphenyl)-5-phenylpenta-2, 4-dien-1-one (CPNC). Material & …
Insights of potential trypanocidal effect of the synthetic derivative (2E)-1-(4-aminophenyl)-3-(2, 4-dichlorophenyl) prop-2-en-1-one: in vitro assay, MEV analysis …
MM Marinho, MN da Rocha, EP Magalhães… - Naunyn-Schmiedeberg's …, 2024 - Springer
This study aims to evaluate the antitrypanosomiasis activity of a synthetic dichloro-
substituted aminochalcone via in vitro assays against infected cell cultures, as well as a …
substituted aminochalcone via in vitro assays against infected cell cultures, as well as a …
Isolation, characterization and in silico study of propenamide alkaloids from Hymenoepmecis bicolor poison against active μ-opioid receptor
A Marques da Fonseca, A Freire da Silva… - Journal of …, 2023 - Taylor & Francis
Some insects produce venoms to defend against predators and directly interact with opioid
receptors. In the present study, it was identified two alkaloids in the wasp venom species …
receptors. In the present study, it was identified two alkaloids in the wasp venom species …
Efeito tripanocida in silico e in vitro de P-aminochalconas sintéticas
NDB Gomes - 2023 - repositorio.ufc.br
RESUMO A doença de Chagas (DC) é uma doença tropical negligenciada de preocupação
mundial em saúde, causada pelo protozoário flagelado Trypanosoma cruzi, sendo …
mundial em saúde, causada pelo protozoário flagelado Trypanosoma cruzi, sendo …
Withanolides of Athenaea velutina with potential inhibitory properties against SARS coronavirus main protease (mpro): molecular modeling studies
P Abreu Alves, KA Dantas Rocha… - Journal of …, 2023 - Taylor & Francis
Since the global COVID-19 pandemic began, the scientific community has dedicated efforts
to finding effective antiviral drugs to treat or minimize the effects caused by the SARS-CoV-2 …
to finding effective antiviral drugs to treat or minimize the effects caused by the SARS-CoV-2 …
Botanical compounds: A promising control strategy against Trypanosoma cruzi
RZ Abbas, MA Qureshi… - Boletín Latinoamericano y …, 2025 - blacpma.ms-editions.cl
La enfermedad de Chagas, también conocida como tripanosomiasis americana, es
causada por Trypanosoma cruzi. Es una amenaza importante para la salud que afecta a …
causada por Trypanosoma cruzi. Es una amenaza importante para la salud que afecta a …
Avaliação do potencial de ação do Carvacrol e seus análogos sobre receptores da Colecistocinina visando a modulação da dor trigeminal: um estudo in silico
MM Bueno - 2024 - repositorio.ufc.br
RESUMO A dor trigeminal (DT), caracterizada como dor do tipo neuropática, afeta
significativamente a qualidade de vida do paciente, devido não só à sua própria condição …
significativamente a qualidade de vida do paciente, devido não só à sua própria condição …