1, 2, 4-and 1, 3, 4-Oxadiazoles as Scaffolds in the Development of Antiparasitic Agents

P Pitasse-Santos, V Sueth-Santiago… - Journal of the Brazilian …, 2018 - SciELO Brasil
In this review, we present the potential use of the heterocyclic oxadiazole rings in the design
and synthesis of new drugs to treat parasitic infections. We intend to compare herein all the …

Recent advancement in synthesis and bioactivities of 1, 3, 4-oxadiazole

T Chaudhary, PK Upadhyay - Current Organic Synthesis, 2023 - benthamdirect.com
Derivatives of 1, 3, 4-oxadiazole are effective in the treatment and cure of a wide range of
diseases in medical chemistry, while industrial development has shown that they can be …

Synthesis, spectral analysis, antibacterial, antifungal, antioxidant and hemolytic activity studies of some new 2, 5-disubstituted-1, 3, 4-oxadiazoles

SL Dhonnar, RA More, VA Adole, BS Jagdale… - Journal of Molecular …, 2022 - Elsevier
Abstract Series of 1, 3, 4-oxadiazole derivatives (5a–5g and 5h, 5i) were synthesized and
characterized by FT-IR, 1 H NMR, 13 C NMR and HR-MS spectral analysis. All the target …

Synthesis of myrtenal-based nanocellulose/diacylhydrazine complexes with antifungal activity for plant protection

B Li, G Lin, W Duan, X Wang, B Cen - Journal of Agricultural and …, 2021 - ACS Publications
In search of novel bioactive compounds with excellent and broad-spectrum antifungal
activity and nanopesticides with sustained releasing property, a series of novel myrtenal …

[HTML][HTML] A facile synthesis of 1, 3, 4-oxadiazole-based carbamothioate molecules: Antiseizure potential, EEG evaluation and in-silico docking studies

N Rasool, Z Razzaq, SG Khan, S Javaid… - Arabian Journal of …, 2023 - Elsevier
In present work, a series of novel structural hybrids of 1, 3, 4-oxadiazole and carbamothioate
was designed by chemical modification of 2-(4-isobutylphenyl) propanoic acid. Target …

Synthesis, molecular modelling studies and ADME prediction of benzothiazole clubbed oxadiazole-Mannich bases, and evaluation of their anti-diabetic activity …

R Bhutani, DP Pathak, G Kapoor, A Husain, R Kant… - Bioorganic …, 2018 - Elsevier
A small library of new benzothiazole clubbed oxadiazole-Mannich bases (M-1 to M-22) were
synthesized and characterized by IR, NMR, Mass and Elemental analysis results. Molecular …

Anticancer effect of novel luteolin capped gold nanoparticles selectively cytotoxic towards human cervical adenocarcinoma HeLa cells: an in vitro approach

IZ Matić, A Mraković, Z Rakočević, M Stoiljković… - Journal of Trace …, 2023 - Elsevier
Background Although luteolin has been confirmed as potent anticancer agent, its potential
application as therapeutic is limited by its water solubility. To overcome this shortcoming …

Development of oxadiazole-sulfonamide-based compounds as potential antibacterial agents

A Ali, P Hasan, M Irfan, A Uddin, A Khan, J Saraswat… - ACS …, 2021 - ACS Publications
In this work, substituted 1, 2, 4-oxadiazoles (OX1–OX27) were screened against five
bacterial strains, identified to be OX7 and OX11 as growth inhibitors with minimum inhibitory …

Design, Synthesis, ADME, and Anticancer Studies of Newer N-Aryl-5-(3,4,5-Trifluorophenyl)-1,3,4-Oxadiazol-2-Amines: An Insight into Experimental and Theoretical …

M Agarwal, O Afzal, Salahuddin, ASA Altamimi… - ACS …, 2023 - ACS Publications
In continuance of our investigation into the anticancer activity of oxadiazoles, we report here
the preparation of 10 new 1, 3, 4-oxadiazole analogues using the scaffold hopping …

Synthesis, antioxidant and antiproliferative activities of 1, 3, 4-thiadiazoles derived from phenolic acids

K Jakovljević, IZ Matić, T Stanojković… - Bioorganic & medicinal …, 2017 - Elsevier
Abstract Two 2-amino-1, 3, 4-thiadiazoles containing phenolic hydroxyl groups were
combined with different carboxylic acid chlorides giving sixteen amide derivatives with good …