The discovery of vitamin E (α-tocopherol) began in 1922 as a vital component required in
reproduction. Today, there are eight naturally occurring vitamin E isoforms, namely α-, β-, γ …

Vitamin E modulates signal transduction pathways by several molecular mechanisms. As a
hydrophobic molecule located mainly in membranes it contributes together with other lipids …

Gasdermin (GSDM) family proteins, known as the executors of pyroptosis, undergo protease-
mediated cleavage before inducing pyroptosis. We here discovered a form of pyroptosis …

The initial steps in preclinical drug developing research concern the synthesis of new
compounds for specific therapeutic use which needs to be confirmed by in vitro and then in …

Vitamin E modulates the activity of several signal transduction enzymes with consequent
alterations of gene expression. At the molecular level, vitamin E may directly bind to these …

High fidelity and effective adaptive changes of the cell and tissue metabolism to changing
environments require strict coordination of numerous biological processes. Multicellular …

In addition to serving as respiratory electron shuttle, ferri-cytochrome c (cyt c) acts as a
peroxidase; ie, it catalyzes the oxidation of organic substrates by H2O2. This peroxidase …

Respiratory complex II (CII, succinate dehydrogenase, SDH) inhibition can induce cell
death, but the mechanistic details need clarification. To elucidate the role of reactive oxygen …

Fe‐S centers exhibit strong electronic plasticity, which is of importance for insuring fine
redox tuning of protein biological properties. In accordance, Fe‐S clusters are also highly …

Clearance of apoptotic debris is a vital role of the innate immune system. Drawing upon
principles of apoptotic clearance, convenient delivery vehicles including intrinsic anti …