Lipid quality control and ferroptosis: from concept to mechanism

Z Li, M Lange, SJ Dixon… - Annual Review of …, 2023 - annualreviews.org
Cellular quality control systems sense and mediate homeostatic responses to prevent the
buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage …

[HTML][HTML] Roles of milk fat globule membrane on fat digestion and infant nutrition

C Chai, S Oh, JY Imm - Food Science of Animal Resources, 2022 - ncbi.nlm.nih.gov
Milk fats are present as globules emulsified in the aqueous phase of milk and stabilized by a
delicate membrane architecture called milk fat globule membrane (MFGM). The unique …

Lipid Peroxidation Drives Liquid–Liquid Phase Separation and Disrupts Raft Protein Partitioning in Biological Membranes

M Balakrishnan, AK Kenworthy - Journal of the American …, 2024 - ACS Publications
The peroxidation of membrane lipids by free radicals contributes to aging, numerous
diseases, and ferroptosis, an iron-dependent form of cell death. Peroxidation changes the …

Membrane Epilipidome—Lipid Modifications, Their Dynamics, and Functional Significance

S Penkov, M Fedorova - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
Lipids are characterized by extremely high structural diversity translated into a wide range of
physicochemical properties. As such, lipids are vital for many different functions including …

Extracellular vesicles as a promising source of lipid biomarkers for breast cancer detection in blood plasma

E Dorado, ML Doria, A Nagelkerke… - Journal of …, 2024 - Wiley Online Library
Extracellular vesicles (EVs), including exosomes and microvesicles, mediate intercellular
communication in cancer, from development to metastasis. EV‐based liquid biopsy is a …

Epimedium koreanum Nakai–Induced Liver Injury—A Mechanistic Study Using Untargeted Metabolomics

P Li, L Zhang, Z Guo, Q Kang, C Chen, X Liu… - Frontiers in …, 2022 - frontiersin.org
Epimedii Folium is widely used worldwide as an herbal supplement, and the risk of its
induced liver damage has emerged in recent years. Our preliminary study has found that …

[HTML][HTML] Oxidative stress is inhibited by plant-based supplements: A quantitative lipidomic analysis of antioxidant activity and lipid compositional change

J Bahja, NA Stewart, MK Dymond - Advances in Redox Research, 2022 - Elsevier
Dietary supplements containing plant extracts are often marketed as having antioxidant
properties. Using complex lipid mixtures derived from cellular tissue, we perform a targeted …

Juggling with lipids, a game of Russian roulette

M Aldrovandi, M Fedorova, M Conrad - Trends in Endocrinology & …, 2021 - cell.com
Lipid peroxidation (LPO) is the molecular mechanism involved in oxidative damage of
cellular membranes and the hallmark of a nonapoptotic form of cell death, known as …

Lipid composition dictates the rate of lipid peroxidation in artificial lipid droplets

M Lange, PV Wagner, M Fedorova - Free Radical Research, 2021 - Taylor & Francis
Cellular and organismal redox imbalance leading to the accumulation of reactive oxygen
species significantly enhances lipid peroxidation (LPO). LPO is relatively well studied for …

Membrane lipids under norm and pathology

BA Basheer Abdullah Marzoog… - European Journal of …, 2021 - cejsh.icm.edu.pl
Introduction. Lipid is an essential component of the cell and its organelles membrane. The
uniqueness and selectivity of lipids to specific functions and asymmetry of lipid distribution in …