The severe form of COVID-19 is marked by an abnormal and exacerbated immunological
host response favoring to a poor outcome in a significant number of patients, especially …

Transient receptor potential vanilloid-type 4 (TRPV4) cation channel is widely expressed in
all tissues as well as in immune cells and its function as mechanosensitive Ca2+ channel …

SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,
compromising the effectiveness of existing vaccines and neutralizing antibodies. An in-depth …

The advent of cancer immunotherapy based on PD-1 and CTLA-4 immune checkpoint
blockade (ICB) has revolutionized cancer treatment. However, many cancers do not respond …

Objective Inflammation and oxidative stress play critical roles in sepsis-induced acute lung
injury (ALI). Sprout4 (Spry4) is involved in regulating inflammation and tissue injury; …

Lethality of coronavirus disease (COVID-19) during the 2020 pandemic, currently still in the
exponentially accelerating phase in most countries, is critically driven by disruption of the …

Macrophages play a central role in dictating the tissue response to infection and
orchestrating subsequent repair of the damage. In this context, macrophages residing in the …

Objective Inflammation and oxidative stress contribute to the progression of sepsis-induced
acute lung injury (ALI). SAM domain, SH3 domain and nuclear localization signals 1 …

Transient receptor ion channels have emerged as immensely important channels/receptors
in diverse physiological and pathological responses. Of particular interest is the transient …

Transient receptor potential vanilloid 4 (TRPV4) is a non-selective mechanosensitive ion
channel expressed by various macrophage populations. Recent reports have characterized …