Recent years have been transformational in regard to the perception of the health risks and
benefits of cannabis with increased acceptance of use. This has unintended …

The endocannabinoid system (ECS) is a widespread neuromodulatory system that plays
important roles in central nervous system development, synaptic plasticity, and the response …

Cannabis elicits its mood-enhancing and analgesic effects through the cannabinoid receptor
1 (CB1), a G protein-coupled receptor (GPCR) that signals primarily through the adenylyl …

In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

The endocannabinoid (eCB) system has emerged as a central integrator linking the
perception of external and internal stimuli to distinct neurophysiological and behavioural …

Microglia are key to maintaining the homeostasis of the brain. These immune cells of the
brain can be our biggest ally in fighting infections, but can worsen pathology or hinder …

Chronic pain states are highly prevalent and yet poorly controlled by currently available
analgesics, representing an enormous clinical, societal, and economic burden. Existing pain …

Adolescence is defined as a transitional period between childhood and adulthood
characterized by changes in social interaction and acquisition of mature cognitive abilities …

Endocannabinoids (eCBs) are endogenous ligands of the cannabinoid receptor 1 (CB1), a
G protein-coupled receptor that regulates a number of therapeutically relevant physiological …

The locus coeruleus (LC) is a small nucleus in the pons from which ascending and
descending projections innervate major parts of the central nervous system. Its major …