Piperidine derivatives: recent advances in synthesis and pharmacological applications

NA Frolov, AN Vereshchagin - International Journal of Molecular Sciences, 2023 - mdpi.com
Piperidines are among the most important synthetic fragments for designing drugs and play
a significant role in the pharmaceutical industry. Their derivatives are present in more than …

Dimethyl sulfoxide: yesterday's solvent, today's reagent

Z Tashrifi, MM Khanaposhtani… - Advanced Synthesis …, 2020 - Wiley Online Library
Dimethyl sulfoxide (DMSO) has had a long history of use as a polar solvent and active
pharmaceutical ingredient in the past decades. However, in this decade DMSO has attracted …

Recent advances in the use of dimethyl sulfoxide as a synthon in organic chemistry

H Lu, Z Tong, L Peng, Z Wang, SF Yin… - Topics in Current …, 2022 - Springer
Dimethyl sulfoxide (DMSO), as extremely important aprotic polar solvent and reaction
medium, has attracted widespread attention from chemists in recent years due to its wide …

Sulfonamide directivity enables Ni-catalyzed 1, 2-diarylation of diverse alkenyl amines

O Apolinar, VT Tran, N Kim, MA Schmidt, J Derosa… - ACS …, 2020 - ACS Publications
1, 2-Diarylation of alkenyl sulfonamides with aryl iodides and aryl boronic esters under
nickel catalysis is reported. The developed method tolerates coupling partners with …

Redox‐Divergent Construction of (Dihydro) thiophenes with DMSO

H Liu, GC He, CY Zhao, XX Zhang, DW Ji… - Angewandte …, 2021 - Wiley Online Library
Thiophene‐based rings are one of the most widely used building blocks for the synthesis of
sulfur‐containing molecules. Inspired by the redox diversity of these features in nature, we …

Arylative methylation of 2, 3-dihydropyrazines and pyrazinones using dimethyl sulfoxide as a C1 source

K Palit, N Sepay, N Panda - The Journal of Organic Chemistry, 2023 - ACS Publications
Divergent synthesis of α-C–H methylated pyrazines and pyrazinones using dimethyl
sulfoxide as a nonconventional methylating agent under metal-free conditions was reported …

DMSO as a Methine Source in TFA-Mediated One-Pot Tandem Regioselective Synthesis of 3-Substituted-1-Aryl-1H-Pyrazolo-[3,4-b]quinolines from Anilines and …

P Yadav, A Awasthi, S Gokulnath… - The Journal of Organic …, 2021 - ACS Publications
An acid-mediated and DMSO participant one-pot tandem synthesis of 3-substituted-1-aryl-1
H-pyrazolo-[3, 4-b] quinoline from readily available anilines and pyrazolones was achieved …

Access to 2-arylquinazolines via catabolism/reconstruction of amino acids with the insertion of dimethyl sulfoxide

JT Ma, LS Wang, Z Chai, XF Chen, BC Tang… - Chemical …, 2021 - pubs.rsc.org
Quinazoline skeletons are synthesized by amino acid catabolism/reconstruction combined
with the insertion/cyclization of dimethyl sulfoxide for the first time. The amino acid acts as a …

Formal Fluorinative Ring Opening of 2-Benzoylpyrrolidines Utilizing [1, 2]-Phospha-Brook Rearrangement for Synthesis of 2-Aryl-3-fluoropiperidines

A Kondoh, R Ojima, M Terada - Organic Letters, 2021 - ACS Publications
A ring expansion of 2-benzoylpyrrolidines, which involves the formal fluorinative ring
opening utilizing the [1, 2]-phospha-Brook rearrangement under Brønsted base catalysis …

[3+ 1+ 1+ 1] annulation to the pyridine structure in quinoline molecules based on DMSO as a nonadjacent dual-methine synthon: simple synthesis of 3-arylquinolines …

T Yang, H Li, Z Nie, M Su, W Luo, Q Liu… - The Journal of Organic …, 2022 - ACS Publications
A [3+ 1+ 1+ 1] annulation of arylamines, arylaldehydes, and dimethyl sulfoxide (DMSO) to
the pyridine structure in quinolines using DMSO as a nonadjacent dual-methine (═ CH−) …