Current concepts regarding Graves' orbitopathy

L Bartalena, ML Tanda - Journal of Internal Medicine, 2022 - Wiley Online Library
Graves' orbitopathy (GO) is an orbital autoimmune disorder and the main extrathyroidal
manifestation of Graves' disease, the most common cause of hyperthyroidism. GO affects …

Graves' ophthalmopathy

RS Bahn - New England Journal of Medicine, 2010 - Mass Medical Soc
This article reviews the mechanisms that lead to the development of Graves'
ophthalmopathy. A central feature in its development is autoimmunity that involves not only T …

[HTML][HTML] Selenium and the course of mild Graves' orbitopathy

C Marcocci, GJ Kahaly, GE Krassas… - … England Journal of …, 2011 - Mass Medical Soc
Background Oxygen free radicals and cytokines play a pathogenic role in Graves'
orbitopathy. Methods We carried out a randomized, double-blind, placebo-controlled trial to …

Diagnosis and management of Graves disease: a global overview

L Bartalena - Nature Reviews Endocrinology, 2013 - nature.com
Graves disease is an autoimmune disorder characterized by goitre, hyperthyroidism and, in
25% of patients, Graves ophthalmopathy. The hyperthyroidism is caused by thyroid …

Current insights into the pathogenesis of Graves' ophthalmopathy

RS Bahn - Hormone and Metabolic Research, 2015 - thieme-connect.com
Environmental, genetic, and immune factors are at play in the development of the variable
clinical manifestations of Graves' ophthalmopathy (GO). Among the environmental …

Comparative effectiveness of therapies for Graves' hyperthyroidism: a systematic review and network meta-analysis

V Sundaresh, JP Brito, Z Wang… - The Journal of …, 2013 - academic.oup.com
Context: Several treatment options are available for Graves' disease (GD), including
antithyroid drugs (ATDs), radioactive iodine (RAI), and thyroidectomy. Objective: The primary …

Graves' disease

TF Davies, S Andersen, R Latif, Y Nagayama… - Nature reviews Disease …, 2020 - nature.com
Graves' disease (GD) is an autoimmune disease that primarily affects the thyroid gland. It is
the most common cause of hyperthyroidism and occurs at all ages but especially in women …

Randomized, Single Blind Trial of Intravenous versus Oral Steroid Monotherapy in Graves' Orbitopathy

GJ Kahaly, S Pitz, G Hommel… - The Journal of Clinical …, 2005 - academic.oup.com
Context: Glucocorticoids are effective for severe Graves' orbitopathy (GO), which causes
substantial morbidity. The question at issue is how best to use them. Objective: The objective …

Current concepts in the molecular pathogenesis of thyroid-associated ophthalmopathy

Y Wang, TJ Smith - Investigative ophthalmology & visual …, 2014 - iovs.arvojournals.org
Graves' disease (GD) is a common autoimmune condition. At its core, stimulatory
autoantibodies are directed at the thyroid-stimulating hormone receptor (TSHR), resulting in …

A 2013 European survey of clinical practice patterns in the management of Graves' disease

L Bartalena, HB Burch, KD Burman… - Clinical …, 2016 - Wiley Online Library
Summary Objective Management of Graves' disease (GD) in Europe was published in 1987.
Aim of this survey was to provide an update on clinical practice in Europe, and to compare it …