Synaptic loss is a pathological feature of all neurodegenerative diseases including
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ALS is a disease of …

Autophagy is a fundamental homeostatic pathway that mediates the degradation and
recycling of intracellular components. It serves as a key quality control mechanism …

The proteasome, the major protein-degradation machine in cells, regulates neuronal
synapses and long-term information storage. Here, using super-resolution microscopy, we …

While cellular proteins were initially thought to be stable, research over the last decades has
firmly established that intracellular protein degradation is an active and highly regulated …

Research in the past twenty years or so has revealed that neurons synthesize and degrade
proteins at their synapses to enable synaptic proteome remodelling on demand and in real …

Local protein synthesis in mature brain axons regulates the structure and function of
presynaptic boutons by adjusting the presynaptic proteome to local demands. This crucial …

Protein homeostasis or “proteostasis” represent the process that regulates the balance of the
intracellular functional and “healthy” proteins. Proteostasis is fundamental to preserve …

While post-transcriptional control is thought to be required at the periphery of neurons and
glia, its extent is unclear. Here, we investigate systematically the spatial distribution and …

Amyotrophic lateral sclerosis damages proteostasis, affecting spinal and upper motor
neurons earlier than a subset of cranial motor neurons. To aid disease understanding, we …

Synaptic integrity and function depend on myriad proteins-labile molecules with finite
lifetimes that need to be continually replaced with freshly synthesized copies. Here we …