Protein misfolding and aggregation are known to play a crucial role in a number of important
human diseases (Alzheimer's, Parkinson's, prion, diabetes, cataracts, etc.) as well as in a …

Conspectus Alzheimer's disease (AD) is the most common form of dementia and is
characterized by memory loss and cognitive decline. Approximately 50 million people …

In Alzheimer's disease (AD), soluble oligomers of amyloid-β (Aβ) are emerging as a crucial
entity in driving disease progression as compared to insoluble amyloid deposits. The lacuna …

Background Neuroinflammation is characterized by microglial activation and the increased
levels of cytokines and chemokines in the central nervous system (CNS). Recent evidence …

Mutations in triggering receptor expressed on myeloid cells 2 (TREM2), which has been
proposed to regulate the inflammatory responses and the clearance of apoptotic neurons …

The deposition of amyloid in brain tissue in the context of neurodegenerative diseases
involves the formation of intermediate species—termed oligomers—of lower molecular mass …

The amyloid fold is structurally characterized by a typical cross-β architecture, which is under
debate to represent an energy-favourable folding state that many globular or natively …

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases
worldwide. Formation of amyloid plaques consisting of amyloid-β peptides (Aβ) is one of the …

DNAX-activating protein of 12 kDa (DAP12) is a signaling adapter protein expressed in cells
that participate in innate immune responses. By pairing with different triggering receptors …

The assembly of the β-amyloid peptide (Aβ) to form oligomers and fibrils is closely
associated with the pathogenesis and progression of Alzheimer's disease. Aβ is a shape …