Soil microorganisms shape global element cycles in life and death. Living soil
microorganisms are a major engine of terrestrial biogeochemistry, driving the turnover of soil …

Concerns over climate change have necessitated a rethinking of our transportation
infrastructure. One possible alternative to carbon-polluting fossil fuels is biofuels produced …

Enzymatic deconstruction of poly (ethylene terephthalate)(PET) is under intense
investigation, given the ability of hydrolase enzymes to depolymerize PET to its constituent …

In recent years, Earth system sciences are urgently calling for innovation on improving
accuracy, enhancing model intelligence level, scaling up operation, and reducing costs in …

Retrobiosynthesis provides an effective and sustainable approach to producing functional
molecules. The past few decades have witnessed a rapid expansion of biosynthetic …

Abstract The bacterial metadatabase Bac Dive (https://bacdive. dsmz. de) has developed
into a leading database for standardized prokaryotic data on strain level. With its current …

Fostered by novel analytical techniques, digitalization, and automation, modern bioprocess
development provides large amounts of heterogeneous experimental data, containing …

While decomposition of organic matter by bacteria plays a major role in nutrient cycling in
terrestrial ecosystems, the significance of viruses remains poorly understood. Here we …

Designing protein mutants with both high stability and activity is a critical yet challenging
task in protein engineering. Here, we introduce PRIME, a deep learning model, which can …

Highlights•Application of machine learning in biotechnology is becoming essential.•Machine
learning is increasingly applied to advance systems metabolic engineering.•Machine …