The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …

This review will focus on how bile acids are being used in clinical trials to treat neurological
diseases due to their central involvement with the gut-liver-brain axis and their physiological …

A metabolic illness known as non-alcoholic fatty liver disease (NAFLD), affects more than
one-quarter of the world's population. Bile acids (BAs), as detergents involved in lipid …

Cholesterol homeostasis is crucial for cellular and systemic function. The disorder of
cholesterol metabolism not only accelerates the onset of cardiovascular disease (CVD) but …

Phytosterols are lipophilic compounds found in plants with structural similarity to mammalian
cholesterol. They cannot be endogenously produced by mammals and therefore always …

On murine N2a cells, 7-ketocholesterol induced an oxiapotophagic mode of cell death
characterized by oxidative stress (reactive oxygen species overproduction on whole cells …

Currently, there is no effective treatment for Parkinson's disease (PD), and the regenerative
treatment of neural stem cells (NSCs) is considered the most promising method. This study …

Dysregulated cholesterol metabolism has been linked to neurodegeneration. We previously
found that free, non-esterified, 7α,(25R) 26-dihydroxycholesterol (7α, 26-diHC), was …

Ocular degeneration, including cataracts, glaucoma, macular degeneration, and diabetic
retinopathy, is a major public health challenge, as it affects the quality of life of millions of …

Phytosterols are lipophilic compounds found in plants with structural similarity to mammalian
cholesterol. They cannot be endogenously produced by mammals and therefore always …