Nature is enriched with a wide variety of complex, synergistic, and highly functional protein-
based multicomponent assemblies. As such, nature has served as a source of inspiration for …

Topology is an intriguing topic in chemistry and an important molecular attribute for
macromolecules. Herein, we discuss the concept of topology in different contexts to clarify …

The chemical topology is a unique dimension for protein engineering, yet the topological
diversity and architectural complexity of proteins remain largely untapped. Herein, we report …

Bioconjugation is a powerful protein modification strategy to improve protein properties.
Herein, we report mechano-bioconjugation as a novel approach to empower fusion protein …

Chemical topology has emerged as one intriguing feature in protein engineering. Nature
demonstrates the elegance and power of protein topology engineering in the unique …

Cyclization and polymer conjugation are two commonly used approaches for enhancing the
pharmacological properties of protein drugs. However, cyclization of parental proteins often …

Unlike small molecules, the topological complexity of macromolecules remains largely
unexplored due to the huge synthetic challenge. Herein, we report the development of …

Entangled proteins have attracted significant research interest. Herein, we report the first
rationally designed lasso proteins, or protein [1] rotaxanes, by using a p53dim‐entwined …

Catenanes are intriguing molecular architectures with unique properties. Herein, we report
the cellular synthesis of protein catenanes containing folded structural domains, aided by …

Design of proteins with nonlinear topologies has emerged as a nascent branch of protein
engineering, but significant applications remain to be seen. Here, we demonstrate the …