Enormous progress has been made in the last half-century in the management of diseases
closely integrated with excess body weight, such as hypertension, adult-onset diabetes and …

The World Health Organization (WHO) refers to obesity as abnormal or excessive fat
accumulation that presents a health risk. Obesity was first designated as a disease in 2012 …

Growth hormone (GH) and insulin-like growth factor-1 (IGF-I) are pleiotropic hormones with
important roles in lifespan. They promote growth, anabolic actions, and body maintenance …

Ghrelin, an endogenous brain–gut peptide, is secreted in large quantities, mainly from the
stomach, in humans and rodents. It can perform the biological function of activating the …

Objective The hormone liver-expressed antimicrobial peptide-2 (LEAP2) is a recently
identified antagonist and an inverse agonist of the growth hormone secretagogue receptor …

Ghrelin exerts key effects on islet hormone secretion to regulate blood glucose levels. Here,
we sought to determine whether ghrelin's effects on islets extend to the alteration of islet size …

Background Growing evidence suggests the key role of ghrelin in the onset and progression
of nonalcoholic fatty liver disease (NAFLD). The potential participation of ghrelin and the …

Despite the growing popular interest in sleep and diet, many gaps exist in our scientific
understanding of the interaction between circadian rhythms and metabolism. In this Review …

The global burden of obesity and the challenges of prevention prompted researchers to
investigate the mechanisms that control food intake. Food ingestion triggers several …

The stress response is an adaptive means of maintaining physiological homeostasis in the
face of changing environmental conditions. However, protracted recruitment of stress …