Nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are
natural biopolymers composed of nucleotides that store, transmit, and express genetic …

The ERBB or EGF receptor (EGFR) proto-oncogene family, which consists of four structurally-
related transmembrane receptors (ie, EGFR, ErbB2, ErbB3, and ErbB4), plays an etiological …

Background The response rate of ovarian mucinous carcinomas to paclitaxel/carboplatin is
low, prompting interest in targeted molecular therapies. We investigated HER2 expression …

Background Ovarian cancer (OC) ranks fifth as a cause of gynecological cancer-associated
death globally. Until now, the molecular mechanisms underlying the tumorigenesis and …

The polymerase chain reaction (PCR) has become one of the most important tools in
molecular diagnostics, providing exquisite sensitivity and specificity for detection of nucleic …

Background Despite a typically good response to first-line combination chemotherapy, the
prognosis for patients with advanced ovarian cancer remains poor because of acquired …

The present study was designed to explore the cross talk between fatty acid synthase
(FASN) and HER2 (ErbB2) in ovarian cancer. A total of 60 ovarian cancer patients and 15 …

The HER2 oncogene encodes a transmembrane protein partially homologous to epidermal
growth factor receptor. This oncogene has been studied mainly in breast cancer where it has …

EGFR and erbB-2 are targets for specific cancer therapy. The purpose of this study was to
examine the frequency and clinicopathological correlations of gene amplification, protein …

Purpose Presence of intratumoral T-cell infiltration has been linked to improved survival in
ovarian cancer patients. We questioned whether antibody immunity specific for ovarian …