NAFLD: mechanisms, treatments, and biomarkers

F Nassir - Biomolecules, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-associated fatty liver
disease (MAFLD), is one of the most common causes of liver diseases worldwide. NAFLD is …

Epidemiologic, genetic, pathogenic, metabolic, epigenetic aspects involved in NASH-HCC: current therapeutic strategies

J Gutiérrez-Cuevas, S Lucano-Landeros… - Cancers, 2022 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is an aggressive human cancer and is
caused as consequences of chronic liver diseases. Although HCC is more common in …

Nonalcoholic fatty liver disease (NAFLD): pathogenesis and noninvasive diagnosis

V Dorairaj, SA Sulaiman, N Abu, NA Abdul Murad - Biomedicines, 2021 - mdpi.com
The global prevalence of nonalcoholic fatty liver disease (NAFLD) or metabolic associated
fatty liver disease (MAFLD), as it is now known, has gradually increased. NAFLD is a …

circMAP3K4 regulates insulin resistance in trophoblast cells during gestational diabetes mellitus by modulating the miR-6795-5p/PTPN1 axis

R Du, N Wu, Y Bai, L Tang, L Li - Journal of Translational Medicine, 2022 - Springer
Background Insulin resistance (IR) during gestational diabetes mellitus (GDM) has been
linked to dysregulated insulin-PI3K/Akt pathway. A defective insulin-PI3K/Akt pathway and …

LncRNA MEG3 up-regulates SIRT6 by ubiquitinating EZH2 and alleviates nonalcoholic fatty liver disease

D Zou, L Liu, Y Zeng, H Wang, D Dai, M Xu - Cell Death Discovery, 2022 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is a global health threat. Here, we presented the
significant role of a novel signaling axis comprising long non-coding RNA maternally …

Nonalcoholic fatty liver disease: focus on new biomarkers and lifestyle interventions

M Notarnicola, AR Osella, MG Caruso… - International journal of …, 2021 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is considered a hepatic manifestation of metabolic
syndrome, characterized from pathological changes in lipid and carbohydrate metabolism …

Non-coding RNAs: novel players in insulin resistance and related diseases

C Formichi, L Nigi, GE Grieco, C Maccora… - International Journal of …, 2021 - mdpi.com
The rising prevalence of metabolic diseases related to insulin resistance (IR) have stressed
the urgent need of accurate and applicable tools for early diagnosis and treatment. In the …

Upregulated lncRNA HCG18 in patients with non-alcoholic fatty liver disease and its regulatory effect on insulin resistance

Y Xia, Y Zhang, H Wang - Diabetes, Metabolic Syndrome and …, 2021 - Taylor & Francis
Purpose Non-alcoholic fatty liver disease (NAFLD) is a disease associated with genetic-
environmental-metabolic stress, which severely damages the liver function of patients. This …

Circular RNAs, Noncoding RNAs, and N6-methyladenosine Involved in the Development of MAFLD

M Nakashima, N Suga, Y Ikeda, S Yoshikawa… - Non-coding RNA, 2024 - mdpi.com
Noncoding RNAs (ncRNAs), including circular RNAs (circRNAs) and N6-methyladenosine
(m6A), have been shown to play a critical role in the development of various diseases …

Dietary patterns influence target gene expression through emerging epigenetic mechanisms in nonalcoholic fatty liver disease

M Zaiou, R Amrani, B Rihn, T Hajri - Biomedicines, 2021 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) refers to the pathologic buildup of extra fat in the
form of triglycerides in liver cells without excessive alcohol intake. NAFLD became the most …