Synthesis, In vitro and In silico Studies of Novel Bis‐triazolopyridopyrimidines from Curcumin Analogues as Potential Aromatase Agents

SM Gomha, AAAA El‐Sayed, MEA Zaki… - Chemistry & …, 2024 - Wiley Online Library
Breast cancer remains a major global health issue, particularly affecting women and
contributing significantly to mortality rates. Current treatments for estrogen receptor‐positive …

1, 2, 4-Triazole derivatives as novel and potent antifungal agents: Design, synthesis and biological evaluation

S Sadeghian, L Emami, A Mojaddami, Z Faghih… - Journal of Molecular …, 2023 - Elsevier
Fungal infections are still threatening human health due to resistance to existing drugs,
therefore, the design and development of novel antifungal agents is to be necessary and …

Design, synthesis and evaluation of novel 1, 2, 4-triazole derivatives as promising anticancer agents

L Emami, S Sadeghian, A Mojaddami, S Khabnadideh… - BMC chemistry, 2022 - Springer
Herein, we reported the synthesis of nineteen novel 1, 2, 4-triazole derivatives including 1, 3-
diphenyl-2-(1H-1, 2, 4-triazol-1-yl) propan-1-ones (7a-e), 1-(1, 3-diphenylpropan-2-yl)-1 H-1 …

New Fluoroquinolone‐1,2,4‐triazoles as Potent Antibacterial Agents: Design, Synthesis, Docking Studies and in Silico ADME Profiles

V Rao Gollapalli, H Babu Bollikolla… - Chemistry & …, 2023 - Wiley Online Library
Our current work is aimed at synthesizing novel substituted 1, 2, 4‐triazolyl‐fluoroquinolone
analogs and study of their biological activity to find active promising molecules. The …

Exploration of triazole derivatives, SAR profiles, and clinical pipeline against Mycobacterium tuberculosis

K Pakeeraiah, KK Chinchilli, R Dandela… - Bioorganic …, 2024 - Elsevier
Tuberculosis is a highly infectious disease and it is a global threat in particular affecting
people from developing countries. It is thought that nearly one-third of the global population …

Novel Antitubercular Agents: Design, Synthesis, Molecular Dynamic and Biological Studies of Pyrazole–1, 2, 4‐Triazole Conjugates

KA Ajin, S Arun Kumar, M Singh… - Chemistry & …, 2023 - Wiley Online Library
Mycobacterium tuberculosis (Mtb) has numerous cell wall and non‐cell wall mediated
receptors for drug action, of which cell wall mediated targets were found to be more …

Screening for antimicrobial and antioxidant activities of quinazolinone based isoxazole and isoxazoline derivatives, synthesis and In silico studies

N Myakala, V Thumma, K Kandula, N Rayala… - Molecular Diversity, 2024 - Springer
Two novel series of quinazolinone based isoxazole and isoxazoline hybrid compounds
were synthesized from 6-aminoquinazolinone as a key precursor. The title compounds were …

[PDF][PDF] Synthesis and Evaluation of Antibacterial and Antifungal Profile of Some Newer Isoxazole Analogous

H Verma, D Pathak, U Singh - Int. J. Pharm. Sci. Drug Res, 2023 - researchgate.net
A new series of 5-(chloromethyl)-3-(substituted phenyl) isoxazole was synthesized in the
presence of sodium hydroxide, substituted aromatic aldehyde (1) combine to produce oxime …

[PDF][PDF] Design, synthesis and evaluation of novel 1, 2, 4-triazole derivatives as promising anticancer agents

H Sadeghpour, Z Faghih, M Fereidoonnezhad… - 2022 - bmcchem.biomedcentral.com
Herein, we reported the synthesis of nineteen novel 1, 2, 4-triazole derivatives including 1, 3-
diphenyl-2-(1H-1, 2, 4-triazol-1-yl) propan-1-ones (7a-e), 1-(1, 3-diphenylpropan-2-yl)-1H-1 …

ADME, Synthesis and Antimycobacterial Activity of 1, 2, 4-Triazol-3-thiol Linked Phenylacetamide Derivatives

T Chitre, S Jadhav, K Asgaonkar… - Current Indian …, 2023 - benthamdirect.com
Background Tuberculosis (TB) is caused by Mycobacterium tuberculosis and is one of the
most contagious and fatal human pathogens which necessitates the development of …