Voltage-gated sodium channels (VGSCs) are key mediators of intrinsic neuronal and muscle
excitability. Abnormal VGSC activity is central to the pathophysiology of epileptic seizures …

This review considers how recent advances in the physiology of ion channels and other
potential molecular targets, in conjunction with new information on the genetics of idiopathic …

Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for
investigators who are searching for the most appropriate laboratory models to address key …

Spike‐wave seizures are often considered a relatively “pure” form of epilepsy, with a uniform
defect present in all patients and involvement of the whole brain homogenously. Here, we …

Typical absence has long been considered as the prototypic form of generalized
nonconvulsive epileptic seizures. Recent investigations in patients and animal models …

Background Mutations of SCN8A encoding the neuronal voltage-gated sodium channel
NaV1. 6 are associated with early-infantile epileptic encephalopathy type 13 (EIEE13) and …

IMPLICATIONS: While anesthetic-induced generalized tonic-clonic convulsions are rare,
electroencephalographic seizure-like activity is common and may not be entirely benign …

First characterized in 1982, the genetic absence epilepsy rat from Strasbourg (GAERS) has
emerged as an animal model highly reminiscent of a specific form of idiopathic generalized …

Voltage-gated sodium channel blockers are one of the vital targets for the management of
several central nervous system diseases, including epilepsy, chronic pain, psychiatric …

Epileptic seizures cause dynamic, reversible changes in brain function and are often
associated with loss of consciousness. Of all seizure types, absence seizures lead to the …