An understanding of the mechanism by which minor groove binding agents interact with
DNA has led to the design of agents that can reversibly bind with high selectivity to extended …

Agents which can recognize and bind specific sequences of DNA offer selective therapy
through the modulation of specific transcription factors or genes. Recently, there has been …

Antibiotic resistance is now a major threat to human health, and one approach to combating
this threat is to develop resistance-resistant antibiotics. Synthetic antimicrobial polymers are …

The binding characteristics of ferulic acid (FA) with bovine serum albumin (BSA) were
investigated using fluorescence, circular dichroism (CD) and isothermal titration calorimetry …

Addressing the global challenge of bacterial resistance demands innovative approaches,
among which multitargeting is a widely used strategy. Current strategies of multitargeting …

Methylation of DNA and histone proteins are mutually involved in the epigenetic regulation
of gene expression mediated by DNA methyltransferases (DNMTs) and histone …

Ligand-induced stabilization of G-quadruplex structures formed by the human telomeric
DNA is an active area of research. The compounds which stabilize the G-quadruplexes often …

The enzyme telomerase synthesizes the G-rich DNA strands of the telomere and its activity
is often associated with cancer. The telomerase may be therefore responsible for the ability …

Alpha-synuclein (aSyn) is a vertebrate protein, normally found within the presynaptic nerve
terminal and nucleus, which is known to form somatic and neuritic aggregates in certain …

At the end of the last century tariquidar (XR9576) was synthesized, pharmacologically
investigated, and classified as a promising 3rd generation P-glycoprotein (P-gp) modulator …