Inorganic biomaterials for regenerative medicine

AM Brokesh, AK Gaharwar - ACS applied materials & interfaces, 2020 - ACS Publications
Regenerative medicine leverages the innate potential of the human body to efficiently repair
and regenerate damaged tissues using engineered biomaterials. By designing responsive …

Design, clinical translation and immunological response of biomaterials in regenerative medicine

K Sadtler, A Singh, MT Wolf, X Wang… - Nature Reviews …, 2016 - nature.com
The field of regenerative medicine aims to replace tissues lost as a consequence of disease,
trauma or congenital abnormalities. Biomaterials serve as scaffolds for regenerative …

Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency

RJ McMurray, N Gadegaard, PM Tsimbouri… - Nature materials, 2011 - nature.com
There is currently an unmet need for the supply of autologous, patient-specific stem cells for
regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by …

[HTML][HTML] Biomaterial-induced pathway modulation for bone regeneration

S Vermeulen, ZT Birgani, P Habibovic - Biomaterials, 2022 - Elsevier
Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …

Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow

D Baksh, R Yao, RS Tuan - Stem cells, 2007 - academic.oup.com
Human umbilical cord perivascular cells (HUCPVCs) have been shown to have a high
proliferative potential and the capacity to differentiate into an osteogenic phenotype …

Bioinorganics and biomaterials: bone repair

P Habibovic, JE Barralet - Acta biomaterialia, 2011 - Elsevier
The field of bioinorganics is well established in the development of a variety of therapies.
However, their application to bone regeneration, specifically by way of localized delivery …

[HTML][HTML] Signaling and transcriptional regulation in osteoblast commitment and differentiation

W Huang, S Yang, J Shao, YP Li - Frontiers in bioscience: a journal …, 2007 - ncbi.nlm.nih.gov
The major event that triggers osteogenesis is the transition of mesenchymal stem cells into
bone forming, differentiating osteoblast cells. Osteoblast differentiation is the primary …

Bone regeneration: molecular and cellular interactions with calcium phosphate ceramics

F Barrère, CA van Blitterswijk… - International journal of …, 2006 - Taylor & Francis
Calcium phosphate bioceramics are widely used in orthopedic and dental applications and
porous scaffolds made of them are serious candidates in the field of bone tissue …

miR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop

K Kapinas, C Kessler, T Ricks, G Gronowicz… - Journal of Biological …, 2010 - ASBMB
Differentiation of human mesenchymal stem cells into osteoblasts is controlled by
extracellular cues. Canonical Wnt signaling is particularly important for maintenance of bone …

Wnt signaling controls the fate of mesenchymal stem cells

L Ling, V Nurcombe, SM Cool - Gene, 2009 - Elsevier
Multipotential mesenchymal stem cells (MSCs) are able to differentiate along several known
lineages and have been shown to be efficacious for in vivo wound repair. The growth and …