Asymmetric catalytic multicomponent cascade reactions have become indispensable tools
for enantioselective construction of spirooxindoles. In recent years, a number of successful …

The enantioselective synthesis of spirocycles has long been pursued by organic chemists.
Despite their unique 3D properties and presence in several natural products, the difficulty in …

The enantioselective synthesis of molecules containing quaternary stereocenters is a field of
intense research interest and development. Among the known organic transformations …

The search for novel anticancer agents with more selectivity and lower toxicity continues to
be an area of intensive investigation. The unique structural features of spirooxindoles …

The catalytic enantioselective assembly of spirocyclic molecules featuring a spiro quaternary
carbon stereocenter is currently of great interest because such privileged 3D structures are …

1. INTRODUCTION Indoline-2, 3-dione or indole-1H-2, 3-dione (Figure 1), commonly known
as isatin, is a well-known natural product found in plants of genus Isatis and in Couropita …

Antiviral therapeutics with profiles of high potency, low resistance, panserotype, and low
toxicity remain challenging, and obtaining such agents continues to be an active area of …

The asymmetric organocatalysis is definitely one of the most powerful and versatile tools for
the rapid construction of various spirocyclic oxindoles. In the past few years, a number of …

Spirocyclic motifs are emerging privileged structures for drug discovery. They are also
omnipresent in the natural products domain. However, until today, no attempt to analyze the …

The spirooxindole system is the core structure of a variety of medicinal agents and natural
products. 1, 2 In fact, spirooxindole derivatives have been described with different biological …