Stereoselective reduction of dehydroamino acids is a common biosynthetic strategy to
introduce d-amino acids into peptidic natural products. The reduction, often observed during …

Many of the biosynthetic pathways for ribosomal synthesized and post-translationally
modified peptide (RiPP) natural products make use of multi-domain enzymes with separate …

Peptide-based drugs have historically been valuable assets in the clinic for combating
disease. Traditionally, natural products have provided a rich source of carefully optimized …