Copper is one of the most abundant basic transition metals in the human body. It takes part
in oxygen metabolism, collagen synthesis, and skin pigmentation, maintaining the integrity …

Ryanodine receptors (RyRs) are located in the sarcoplasmic/endoplasmic reticulum
membrane and are responsible for the release of Ca2+ from intracellular stores during …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Alzheimer's disease (AD) is the most common neurodegenerative disorder with
heterogeneous etiology. Intracellular neurofibrillary tangles caused by tau (τ) protein …

New findings obtained during the past years, especially the discovery of mutations in the
genes associated with brain iron metabolism, have provided key insights into the …

Differential antioxidant action is found upon comparison of organ/tissue systems in the
human body. In erythrocytes (red blood cells), which transport oxygen and carbon dioxide …

Iron (Fe) is an essential element for many metabolic processes, serving as a cofactor for
heme and nonheme proteins. Cellular iron deficiency arrests cell growth and leads to cell …

Formation of reactive oxygen and nitrogen species is a precipitating event in an array of
neuropathological conditions. In response to excessive reactive oxygen species (ROS) …

The amyloid‐β precursor protein (APP) and its pathogenic byproduct β‐amyloid peptide (Aβ)
play central roles in the pathogenesis of Alzheimer's disease (AD). Reduction in levels of the …

Historically, key cellular regulators of diverse physiological processes have been uncovered
by studying the mechanisms by which chemical entities produce interesting biological …