Neuroprotective natural products for Alzheimer's disease

X Chen, J Drew, W Berney, W Lei - Cells, 2021 - mdpi.com
Alzheimer's disease (AD) is the number one neurovegetative disease, but its treatment
options are relatively few and ineffective. In efforts to discover new strategies for AD therapy …

New insights into drug discovery targeting tau protein

Y Soeda, A Takashima - Frontiers in molecular neuroscience, 2020 - frontiersin.org
Microtubule-associated protein tau is characterized by the fact that it is an intrinsically
disordered protein due to its lack of a stable conformation and high flexibility. Intracellular …

Linking the amyloid, tau, and mitochondrial hypotheses of Alzheimer's disease and identifying promising drug targets

Z Fišar - Biomolecules, 2022 - mdpi.com
Damage or loss of brain cells and impaired neurochemistry, neurogenesis, and synaptic and
nonsynaptic plasticity of the brain lead to dementia in neurodegenerative diseases, such as …

[HTML][HTML] The neuroprotective effect of traditional Chinese medicinal plants—A critical review

J Moreira, M Machado, M Dias-Teixeira… - … Pharmaceutica Sinica B, 2023 - Elsevier
Neurodegenerative and neuropsychiatric diseases are increasingly affecting individuals'
quality of life, thus increasing their cost to social and health systems. These diseases have …

Structure characteristics and immunomodulatory activities of a polysaccharide RGRP-1b from radix ginseng Rubra

X Zhang, Z Liu, C Zhong, Y Pu, Z Yang… - International Journal of …, 2021 - Elsevier
The present study was undertaken to explore the structure characteristics, immune
regulation, and anti-cancer abilities of polysaccharides in radix ginseng Rubra (RGR). For …

Nootropic herbs, shrubs, and trees as potential cognitive enhancers

M Malík, P Tlustoš - Plants, 2023 - mdpi.com
Plant-based nootropics are a diverse group of natural drugs that can improve cognitive
abilities through various physiological mechanisms, especially in cases where these …

[PDF][PDF] Tau-targeting therapy in Alzheimer's disease: Critical advances and future opportunities

Y Guo, S Li, LH Zeng, J Tan - Ageing Neurodegener. Dis, 2022 - f.oaes.cc
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by two
pathological hallmark lesions: extracellular plaques composed of β-amyloid (Aβ) peptide …

Types of memory, dementia, Alzheimer's disease, and their various pathological cascades as targets for potential pharmacological drugs

A Akhtar, S Singh, R Kaushik, R Awasthi… - Ageing Research Reviews, 2024 - Elsevier
Alzheimer's disease (AD) is the most common type of dementia accounting for 90% of cases;
however, frontotemporal dementia, vascular dementia, etc. prevails only in a minority of …

Therapeutic effects of non-saponin fraction with rich polysaccharide from Korean red ginseng on aging and Alzheimer's disease

SJ Shin, Y Nam, YH Park, MJ Kim, E Lee… - Free Radical Biology …, 2021 - Elsevier
Biological aging provokes morbidity and several functional declines, causing older adults
more susceptible to a variety of diseases than younger adults. In particular, aging is a major …

Neuroprotective potentials of Panax ginseng against Alzheimer's disease: a review of preclinical and clinical evidences

J Li, Q Huang, J Chen, H Qi, J Liu, Z Chen… - Frontiers in …, 2021 - frontiersin.org
Alzheimer's disease (AD), a neurodegenerative disorder, is a major health concern in the
increasingly aged population worldwide. Currently, no clinically effective drug can halt the …