Injectable hydrogels based on biopolymers for the treatment of ocular diseases

C Yu, J Xu, G Heidari, H Jiang, Y Shi, A Wu… - International Journal of …, 2024 - Elsevier
Injectable hydrogels based on biopolymers, fabricated utilizing diverse chemical and
physical methodologies, exhibit exceptional physical, chemical, and biological properties …

Advanced drug delivery strategies for diabetic retinopathy: current therapeutic advancement, and delivery methods overcoming barriers, and experimental modalities

M Diress, SR Wagle, P Lim, T Foster… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Diabetic retinopathy, a significant trigger for blindness among working age
individuals with diabetes, poses a substantial global health challenge. Understanding its …

Effects of mesenchymal stromal cells and human recombinant Nerve Growth Factor delivered by bioengineered human corneal lenticule on an innovative model of …

L Pelusi, J Hurst, N Detta, C Pipino… - Frontiers in …, 2024 - frontiersin.org
Introduction Diabetic retinopathy (DR) is a microvascular complication of diabetes in which
neurodegeneration has been recently identified as a driving force. In the last years …

Retina-on-Chip: Engineering Functional in vitro Models of the Human Retina using Organ-on-Chip Technology

EMV Oosten, AD ávan der Meer - Lab on a Chip, 2025 - pubs.rsc.org
The retina is a complex and highly metabolic tissue in the back of the eye essential for
human vision. Retinal diseases can lead to loss of vision in early and late stages of life …

Tocotrienol-rich fraction (TRF) protects against retinal cell apoptosis and preserves visual behavior in rats with streptozotocin-induced diabetic retinopathy

Y Goh, MZ Sadikan, H Jaiprakash, NAA Nasir… - … Medicine and Therapies, 2024 - Springer
Background Tocotrienol is a vitamin E analogue that is known to exert anti-inflammatory and
antioxidant effects. Hence, in the current study, the effects of TRF on the expression of pro …

Resveratrol protects against diabetic retinal ganglion cell damage by activating the Nrf2 signaling pathway

D Yuan, Y Xu, L Xue, W Zhang, L Gu, Q Liu - Heliyon, 2024 - cell.com
Objective Oxidative stress-induced retinal neurodegenerative changes are among the
pathological alterations observed in diabetic retinopathy. Resveratrol (RSV), a polyphenolic …

[HTML][HTML] Methylglyoxal: A Key Factor for Diabetic Retinopathy and Its Effects on Retinal Damage

V Klochkov, CM Chan, WW Lin - Biomedicines, 2024 - pmc.ncbi.nlm.nih.gov
Background: Diabetic retinopathy is the most common retinal vascular disease, affecting the
retina's blood vessels and causing chronic inflammation, oxidative stress, and, ultimately …

Chronic hyperglycemia alters retinal astrocyte microstructure and uptake of cholera toxin B in a murine model of diabetes

JM Holden, OL Bossardet… - Journal of …, 2025 - Wiley Online Library
Astrocytes are the principle glial cells of the central nervous system and play an active role
in maintaining proper metabolism in surrounding neurons. Because of their involvement in …

[HTML][HTML] Identifying the stability of housekeeping genes to be used for the quantitative real-time PCR normalization in retinal tissue of streptozotocin-induced diabetic …

MZ Sadikan, NAA Nasir, MJ Ibahim… - International Journal …, 2024 - ncbi.nlm.nih.gov
AIM To investigate the stability of the seven housekeeping genes: beta-actin (ActB),
glyceraldehyde-3-phosphate dehydrogenase (GAPDH), 18s ribosomal unit 5 (18s) …

The Role of Natural Products in Diabetic Retinopathy

Y Zhao, Y Chen, N Yan - Biomedicines, 2024 - mdpi.com
Diabetic retinopathy (DR) is one of the most severe complications of diabetes mellitus and
potentially leads to significant visual impairment and blindness. The complex mechanisms …