Microbiota-brain interactions: Moving toward mechanisms in model organisms

J Nagpal, JF Cryan - Neuron, 2021 - cell.com
Changes in the microbiota are associated with alterations in nervous system structure-
function and behavior and have been implicated in the etiology of neuropsychiatric and …

Microbiota–gut–brain axis and epilepsy: a review on mechanisms and potential therapeutics

M Ding, Y Lang, H Shu, J Shao, L Cui - Frontiers in Immunology, 2021 - frontiersin.org
The gut–brain axis refers to the bidirectional communication between the gut and brain, and
regulates intestinal homeostasis and the central nervous system via neural networks and …

Higher levels of Bifidobacteria and tumor necrosis factor in children with drug-resistant epilepsy are associated with anti-seizure response to the ketogenic diet

M Dahlin, SS Singleton, JA David, A Basuchoudhary… - …, 2022 - thelancet.com
Background Recently, studies have suggested a role for the gut microbiota in epilepsy. Gut
microbial changes during ketogenic diet (KD) treatment of drug-resistant epilepsy have been …

Protective effects of long-term probiotic mixture supplementation against pentylenetetrazole-induced seizures, inflammation and oxidative stress in rats

E Kilinc, S Ankarali, D Ayhan, H Ankarali… - The Journal of nutritional …, 2021 - Elsevier
Emerging evidence indicates that dysbiosis of gut microbiota plays an important role in
epilepsy, although the underlying mechanisms remain unclear due to the complex nature of …

Effects of probiotics on GABA/glutamate and oxidative stress in PTZ-induced acute seizure model in rats

AC Ciltas, CE Toy, H Güneş, M Yaprak - Epilepsy Research, 2023 - Elsevier
Studies conducted in recent years have indicated a relationship between epilepsy and gut
microbiota. Ion channels, excitatory/inhibitory balance and regulatory systems play a role in …

[HTML][HTML] Gut microbiome effects on neuronal excitability & activity: Implications for epilepsy

H Darch, CP McCafferty - Neurobiology of disease, 2022 - Elsevier
It is now well established that the bacterial population of the gastrointestinal system, known
as the gut microbiome, is capable of influencing the brain and its dependent functions. Links …

[HTML][HTML] The gut microbiota as a biomarker in epilepsy

E Russo - Neurobiology of Disease, 2022 - Elsevier
Biomarkers are defined as objectively measurable variables of a biologic process, either
physiologic or pathologic, that provide reliable information on the status of that specific …

[HTML][HTML] Gut microbiota manipulation as an epilepsy treatment

LF Iannone, M Gómez-Eguílaz, C De Caro - Neurobiology of Disease, 2022 - Elsevier
Many studies have documented the important role of the gut microbiota (GM) in the
regulation of several central nervous system (CNS) processes through the microbiota-gut …

Susceptibility to epilepsy after traumatic brain injury is associated with preexistent gut microbiome profile

JS Medel‐Matus, V Lagishetty, C Santana‐Gomez… - …, 2022 - Wiley Online Library
Objective We examined whether posttraumatic epilepsy (PTE) is associated with
measurable perturbations in gut microbiome. Methods Adult Sprague Dawley rats were …

Disruption of intestinal barrier and endotoxemia after traumatic brain injury: implications for post‐traumatic epilepsy

A Mazarati, JS Medel‐Matus, D Shin, JP Jacobs… - …, 2021 - Wiley Online Library
Objective Traumatic brain injury (TBI) may lead to the disruption of the intestinal barrier (IB),
and to the escape of products of commensal gut bacteria, including lipopolysaccharide …