Abstract Phospholipase A 2 (PLA 2) enzymes are involved in various inflammatory
pathological conditions including arthritis, cardiovascular and autoimmune diseases. The …

ABSTRACT Phospholipase A2 (PLA2) enzymes are implicated in several pathological
conditions such as arthritis, cardiovascular diseases, and diabetes. It is highly important to …

Abstract Palladium (II)‐catalyzed meta‐C− H arylation and alkylation of benzylsulfonamide
using 2‐carbomethoxynorbornene (NBE‐CO2Me) as a transient mediator are realized by …

Peptides and peptidomimetics are emerging as an important class of clinic therapeutics.
Here we report a peptide-guided method for the functionalization and macrocyclization of …

The development of light‐mediated methods for synthetic applications is increasingly
attracting high interest. We present herein a new photochemical protocol for the synthesis of …

Inflammation is a body response against infection that activates other biological components
that include various cytokines, chemokines and other biological compounds that trigger …

Phospholipase A2s (PLA2s) are group of enzymes, which cleave phospholipids specifically
at sn-2 position to liberate free fatty acid, mostly arachidonic acid (AA) and …

Introduction: The regulation of the catalytic activity of the various phospholipase A2 enzymes
is of high importance because these enzymes are involved in various pathological …

Eicosanoids are key players in inflammatory diseases and cancer. Targeting their
production by inhibiting Group IVA cytosolic phospholipase A2 (cPLA2α) offers a promising …

Five-and six-membered heteroaromatic rings and their benzo-fused homologues are well
established as important structural elements in drug design and are well represented in …