The 5-HT1A receptor is highly expressed both in 5-HT neurons as a presynaptic inhibitory
autoreceptor, and in many brain regions innervated by 5-HT as a post-synaptic …

Psychiatric disorders represent a large economic burden in modern societies. However,
pharmacological treatments are still far from optimal. Drugs used in the treatment of major …

Most depressed patients don't respond to their first drug treatment, and the reasons for this
treatment resistance remain enigmatic. Human studies implicate a polymorphism in the …

Abstract Rationale Serotonin (5-HT) neurotransmission is intimately linked to anxiety and
depression and a diverse body of evidence supports the involvement of the main inhibitory …

Serotonin is an important neuromodulator associated with a wide range of physiological
effects in the central nervous system. The exact mechanisms whereby serotonin influences …

The role of serotonin in major depressive disorder (MDD) is the focus of accumulating
clinical and preclinical research. The results of these studies reflect the complexity of …

Identifying the factors contributing to the etiology of anxiety and depression is critical for the
development of more efficacious therapies. Serotonin (5-HT) is intimately linked to both …

Abstract Development passes through sensitive periods, during which plasticity allows for
genetic and environmental factors to exert indelible influence on the maturation of the …

Abstract The serotonin-1A (5-HT1A) receptor is among the most abundant and widely
distributed 5-HT receptors in the brain, but is also expressed on serotonin neurons as an …

Early-life serotonin [5-hydroxytryptamine (5-HT)] signaling modulates brain development,
which impacts adult behavior, but 5-HT-sensitive periods, neural substrates, and behavioral …