RNA interference (RNAi) was discovered less than a decade ago and already there are
human clinical trials in progress or planned. A major advantage of RNAi versus other …

The discovery of RNA interference (RNAi) may well be one of the transforming events in
biology in the past decade. RNAi can result in gene silencing or even in the expulsion of …

RNAi technology has brought a new category of treatments for various diseases including
genetic diseases, viral diseases, and cancer. Despite the great versatility of RNAi that can …

Recently identified hepatitis C virus (HCV) isolates that are infectious in cell culture provide
a genetic system to evaluate the significance of virus–host interactions for HCV replication …

To protect against the harmful consequences of viral infections, organisms are equipped
with sophisticated antiviral mechanisms, including cell‐intrinsic means to restrict viral …

In the past 4 years, RNA interference (RNAi) has become widely used as an experimental
tool to analyse the function of mammalian genes, both in vitro and in vivo. By harnessing an …

Influenza A virus infection is a major source of morbidity and mortality worldwide. Because
the effectiveness of existing vaccines and antiviral drugs is limited, development of new …

In RNA interference (RNAi), short double-stranded RNA (known as siRNA) inhibits
expression from homologous genes. Clinical or pre-clinical use of siRNAs is likely to require …

Influenza virus infection is responsible for hundreds of thousands of deaths annually.
Current vaccination strategies and antiviral drugs provide limited protection; therefore, new …

ABSTRACT CD81 has been described as a putative receptor for hepatitis C virus (HCV);
however, its role in HCV cell entry has not been characterized due to the lack of an efficient …