The percutaneous device dilemma describes etiological factors, centered around the
disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant …

Plectin is a giant cytoskeletal crosslinker and intermediate filament stabilizing protein.
Mutations in the human plectin gene (PLEC) cause several rare diseases that are grouped …

INTRODUCTION Alternative splicing is a posttranscriptional regulatory mechanism critical
for transcriptome and proteome diversity. By increasing complexity at the protein level …

The opportunistic pathogen, Pseudomonas aeruginosa, a flagellated bacterium, is one of
the top model organisms for biofilm studies. To elucidate the location of bacterial flagella …

Background Invadopodia facilitate cancer cell extravasation, but the molecular mechanism
whereby invadopodia-specific proteases such as MT1-MMP are called to invadopodia is …

Epidermolysis bullosa is a group of genetic skin conditions characterized by abnormal skin
(and mucosal) fragility caused by pathogenic variants in various genes. The disease severity …

Plectin is a multi-faceted, 500 kDa-large protein, which due to its expression in different
isoforms and distinct organs acts diversely as a cytoskeletal crosslinker and signaling …

Plakins are large multi-domain proteins that interconnect cytoskeletal structures. Plectin is a
prototypical plakin that tethers intermediate filaments to membrane-associated complexes …

Plectin, a high-molecular-weight cytoskeletal linker protein, binds with high affinity to
intermediate filaments of all types and connects them to junctional complexes, organelles …

Mutations of the human plectin gene (PLEC) on chromosome 8q24 cause autosomal
recessive epidermolysis bullosa simplex with muscular dystrophy (EBS-MD). In the present …