Nonsense-mediated mRNA decay (NMD) is one of the best characterized and most
evolutionarily conserved cellular quality control mechanisms. Although NMD was first found …

Nonsense-mediated RNA decay (NMD) is a highly conserved RNA turnover pathway that
selectively degrades RNAs harbouring truncating mutations that prematurely terminate …

Nonsense-mediated mRNA decay (NMD) is an mRNA quality-control mechanism that
typifies all eukaryotes examined to date. NMD surveys newly synthesized mRNAs and …

Several mechanisms of action have been proposed for DNA methyltransferase and histone
deacetylase inhibitors (DNMTi and HDACi), primarily based on candidate-gene approaches …

The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs
harboring premature termination codons (PTCs) but also regulates the abundance of a large …

Nonsense-mediated RNA decay (NMD) was originally discovered as a cellular surveillance
pathway that safeguards the quality of mRNA transcripts in eukaryotic cells. In its canonical …

Approximately 10% of all pathological mutations are nonsense mutations that are
responsible for several severe genetic diseases for which no treatment regimens are …

Genomic studies in acute myeloid leukemias (AML) have identified mutations that drive
altered DNA methylation, including TET2 and IDH2. Here, we show that models of AML …

Alternative splicing, a fundamental step in gene expression, is deregulated in many
diseases. Splicing factors (SFs), which regulate this process, are up-or down regulated or …

Background The nonsense mutation, c. 3846G> A (aka: W1282X-CFTR) leads to a truncated
transcript that is susceptible to nonsense-mediated decay (NMD) and produces a shorter …