Since the introduction of insulin almost a century ago, more than 80 peptide drugs have
reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis …

Cyclic peptides are fascinating molecules abundantly found in nature and exploited as
molecular format for drug development as well as other applications, ranging from research …

Over 20 years ago, the pyrrolysine encoding translation system was discovered in specific
archaea. Our Review provides an overview of how the once obscure pyrrolysyl-tRNA …

Cyclic peptides are molecules that are already used as drugs in therapies approved for
various pharmacological activities, for example, as antibiotics, antifungals, anticancer, and …

Poisons always have fascinated humankind. Initially considered as deleterious or
hazardous substances, the modern era has witnessed the controlled utilization of dangerous …

Genetically encoded libraries play a crucial role in discovering structurally rigid, high-affinity
macrocyclic peptide ligands for therapeutic applications. Bicyclic peptides with metal centres …

Cyclic peptides can bind challenging disease targets with high affinity and specificity,
offering enormous opportunities for addressing unmet medical needs. However, as with …

Macrocycles have excellent potential as therapeutics due to their ability to bind challenging
targets. However, generating macrocycles against new targets is hindered by a lack of large …

Superior to linear peptides in biological activities, cyclic peptides are considered to have
great potential as therapeutic agents. To identify cyclic‐peptide ligands for therapeutic …

Developing peptide-based tools to fine-tune growth signaling pathways, in particular
molecules with exquisite selectivity and high affinities, opens up opportunities for cellular …