Directional induction of neural stem cells, a new therapy for neurodegenerative diseases and ischemic stroke

L Nie, D Yao, S Chen, J Wang, C Pan, D Wu… - Cell Death …, 2023 - nature.com
Due to the limited capacity of the adult mammalian brain to self-repair and regenerate,
neurological diseases, especially neurodegenerative disorders and stroke, characterized by …

(BIO) ANALYTICAL APPROACHES FOR INVESTIGATING THE ROLE OF SELENIUM IN PREVENTING NEUROLOGICAL DISORDERS AND NEUROTOXICITY …

B Gómez-Gómez, T Fernández-Bautista… - TrAC Trends in Analytical …, 2024 - Elsevier
There is increasing evidence that dysfunction of essential metal (Cu, Zn, Fe, Mn)
homeostasis can lead to the appearance of several NDs. Other neurotoxic environmental …

[HTML][HTML] Psychosis risk candidate ZNF804A localizes to synapses and regulates neurite formation and dendritic spine structure

PJM Deans, P Raval, KJ Sellers, NJF Gatford… - Biological …, 2017 - Elsevier
Background Variation in the gene encoding zinc finger binding protein 804A (ZNF804A) is
associated with schizophrenia and bipolar disorder. Evidence suggests that ZNF804A is a …

Structure Elucidation and Biological Evaluation of Maitotoxin-3, a Homologue of Gambierone, from Gambierdiscus belizeanus

A Boente-Juncal, M Álvarez, Á Antelo, I Rodríguez… - Toxins, 2019 - mdpi.com
Gambierdiscus species are the producers of the marine toxins ciguatoxins and maitotoxins
which cause worldwide human intoxications recognized as Ciguatera Fish Poisoning. A …

Chromosomal structural rearrangements implicate long non-coding RNAs in rare germline disorders

RE Andersen, IF Alkuraya, A Ajeesh, T Sakamoto… - Human Genetics, 2024 - Springer
In recent years, there has been increased focus on exploring the role the non-protein-coding
genome plays in Mendelian disorders. One class of particular interest is long non-coding …

[HTML][HTML] The psychiatric risk gene NT5C2 regulates adenosine monophosphate-activated protein kinase signaling and protein translation in human neural progenitor …

RRR Duarte, ND Bachtel, MC Côtel, SH Lee… - Biological …, 2019 - Elsevier
Abstract Background The 5′-nucleotidase, cytosolic II gene (NT5C2, cN-II) is associated
with disorders characterized by psychiatric and psychomotor disturbances. Common …

Neuroligin-3 and neuroligin-4X form nanoscopic clusters and regulate growth cone organization and size

NJF Gatford, PJM Deans, RRR Duarte… - Human Molecular …, 2022 - academic.oup.com
The cell-adhesion proteins neuroligin-3 and neuroligin-4X (NLGN3/4X) have well described
roles in synapse formation. NLGN3/4X are also expressed highly during neurodevelopment …

Quantitative characterization of phenotypical markers after differentiation of SH-SY5Y cells

AD Ducray, L Wiedmer, F Herren… - CNS & Neurological …, 2020 - ingentaconnect.com
Background: The human neuroblastoma cell line, SH-SY5Y, has been widely used in
neuroscience research, especially in studies related to Parkinson's disease. However …

[HTML][HTML] Chlorpyrifos Acts as a Positive Modulator and an Agonist of N-Methyl-d-Aspartate (NMDA) Receptors: A Novel Mechanism of Chlorpyrifos-Induced …

MA Sherif, WG Carter, IR Mellor - Journal of Xenobiotics, 2025 - mdpi.com
Chlorpyrifos (CPF) is a broad-spectrum organophosphate insecticide. Long-term exposure
to low levels of CPF is associated with neurodevelopmental and neurodegenerative …

In vitro Cell Platform for Understanding Developmental Toxicity

J Xie, K Wettschurack, C Yuan - Frontiers in genetics, 2020 - frontiersin.org
Developmental toxicity and its affiliation to long-term health, particularly neurodegenerative
disease (ND) has attracted significant attentions in recent years. There is, however, a …