[HTML][HTML] The gut microbiome as a modulator of healthy ageing

TS Ghosh, F Shanahan, PW O'Toole - … Reviews Gastroenterology & …, 2022 - nature.com
The gut microbiome is a contributory factor in ageing-related health loss and in several non-
communicable diseases in all age groups. Some age-linked and disease-linked …

[Retracted] Ellagic Acid: A Review on Its Natural Sources, Chemical Stability, and Therapeutic Potential

J Sharifi-Rad, C Quispe, CMS Castillo… - Oxidative medicine …, 2022 - Wiley Online Library
Ellagic acid (EA) is a bioactive polyphenolic compound naturally occurring as secondary
metabolite in many plant taxa. EA content is considerable in pomegranate (Punica granatum …

[HTML][HTML] Impact of the natural compound urolithin A on health, disease, and aging

D D'Amico, PA Andreux, P Valdés, A Singh… - Trends in molecular …, 2021 - cell.com
Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins
(ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate …

[HTML][HTML] Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy

D Denk, V Petrocelli, C Conche, M Drachsler… - Immunity, 2022 - cell.com
T memory stem cells (T SCM) display increased self-renewal and prolonged survival
capabilities, thus preventing T cell exhaustion and promoting effective anti-tumor T cell …

Where to look into the puzzle of polyphenols and health? The postbiotics and gut microbiota associated with human metabotypes

A Cortés‐Martín, MV Selma… - Molecular Nutrition & …, 2020 - Wiley Online Library
The full consensus on the role of dietary polyphenols as human‐health‐promoting
compounds remains elusive. The two‐way interaction between polyphenols and gut …

[HTML][HTML] The two-way polyphenols-microbiota interactions and their effects on obesity and related metabolic diseases

TAF Corrêa, MM Rogero, NMA Hassimotto… - Frontiers in …, 2019 - frontiersin.org
Metabolic diseases can change the gut microbiota composition and function, and
pathogenic bacteria contribute to the development of metabolic disorders. Polyphenols may …

Ellagic acid and intestinal microflora metabolite urolithin A: A review on its sources, metabolic distribution, health benefits, and biotransformation

M Zhang, S Cui, B Mao, Q Zhang, J Zhao… - Critical reviews in …, 2023 - Taylor & Francis
Foods rich in ellagic tannins are first hydrolyzed into ellagic acid in the stomach and small
intestine, and then converted into urolithins with high bioavailability by the intestinal flora …

[HTML][HTML] Main drivers of (poly) phenol effects on human health: metabolite production and/or gut microbiota-associated metabotypes?

CE Iglesias-Aguirre, A Cortés-Martín… - Food & function, 2021 - pubs.rsc.org
Despite the high human interindividual variability in response to (poly) phenol consumption,
the cause-and-effect relationship between some dietary (poly) phenols (flavanols and olive …

[HTML][HTML] The impact of ellagitannins and their metabolites through gut microbiome on the gut health and brain wellness within the gut–brain axis

R Banc, ME Rusu, L Filip, DS Popa - Foods, 2023 - mdpi.com
Ellagitannins (ETs) are a large group of bioactive compounds found in plant-source foods,
such as pomegranates, berries, and nuts. The consumption of ETs has often been …

[HTML][HTML] Urolithins: The gut based polyphenol metabolites of ellagitannins in cancer prevention, a review

SA Al-Harbi, AO Abdulrahman, MA Zamzami… - Frontiers in …, 2021 - frontiersin.org
Cancer as a disease continues to ravage the world population without regard to sex, age,
and race. Due to the growing number of cases worldwide, cancer exerts a significant …