Numerous genetic variants have been shown to be associated with antipsychotic response
and adverse effects of schizophrenia treatment. However, the clinical application of these …

Schizophrenia (SZ) onset and treatment outcome have important genetic components,
however individual genes do not have strong effects on SZ phenotype. Therefore, it is …

Background: Metabolic syndrome is widespread in patients with schizophrenia receiving
long-term antipsychotic therapy. Dopamine D2 receptors play an important role in mediating …

Background Hyperprolactinemia (HPRL) is a classical side effect of antipsychotic drugs
primarily attributed to blockade of dopamine D2 receptors (DRD2s) on the membranes of …

Background: Antipsychotic-induced metabolic syndrome (MetS) is a multifactorial disease
with a genetic predisposition. Serotonin and its receptors are involved in antipsychotic-drug …

Background Antipsychotic drugs can cause hyperprolactinemia. However,
hyperprolactinemia was also observed in treatment-naive patients with a first schizophrenic …

We provide an overview of the recent achievements in psychiatric genetics research in the
Russian Federation and present genotype-phenotype, population, epigenetic, cytogenetic …

Major depressive disorder has become a prominent cause of disability, as lifetime
prevalence has increased to~ 15% in the Western world. Pharmacological effects of …

Introduction Hyperprolactinaemia, a common adverse effect of antipsychotic drugs, is
primarily linked to blockade of dopamine D2 receptors in the pituitary gland. Certain …

The aim of this study was to investigate the association of drug-metabolizing enzyme and
transporter (DMET) polymorphisms with the risperidone-induced prolactin response using …