[HTML][HTML] Molecular mechanisms and therapeutic targets for diabetic kidney disease

KR Tuttle, R Agarwal, CE Alpers, GL Bakris… - Kidney international, 2022 - Elsevier
Diabetic kidney disease has a high global disease burden and substantially increases the
risk of kidney failure and cardiovascular events. Despite treatment, there is substantial …

The evolving metabolic landscape of chromatin biology and epigenetics

Z Dai, V Ramesh, JW Locasale - Nature Reviews Genetics, 2020 - nature.com
Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

[HTML][HTML] The role of advanced glycation end products in aging and metabolic diseases: bridging association and causality

J Chaudhuri, Y Bains, S Guha, A Kahn, D Hall, N Bose… - Cell metabolism, 2018 - cell.com
Accumulation of advanced glycation end products (AGEs) on nucleotides, lipids, and
peptides/proteins are an inevitable component of the aging process in all eukaryotic …

Treatment of NAFLD with diet, physical activity and exercise

M Romero-Gómez, S Zelber-Sagi, M Trenell - Journal of hepatology, 2017 - Elsevier
Lifestyle intervention can be effective when treating non-alcoholic fatty liver diseases
(NAFLD) patients. Weight loss decreases cardiovascular and diabetes risk and can also …

Enteral nutrition in preterm infants (2022): a position paper from the ESPGHAN committee on nutrition and invited experts

ND Embleton, SJ Moltu, A Lapillonne… - Journal of pediatric …, 2023 - journals.lww.com
Objectives: To review the current literature and develop consensus conclusions and
recommendations on nutrient intakes and nutritional practice in preterm infants with …

Targeting RAGE signaling in inflammatory disease

BI Hudson, ME Lippman - Annual review of medicine, 2018 - annualreviews.org
The receptor for advanced glycation end-products (RAGE) is a multiligand pattern
recognition receptor implicated in diverse chronic inflammatory states. RAGE binds and …

Functional and biological properties of Maillard conjugates and their potential application in medical and food: A review

M Nooshkam, M Varidi, DK Verma - Food Research International, 2020 - Elsevier
Protein and peptides are usually sensitive to environmental stresses, such as pH changes,
high temperature, ionic strength, and digestive enzymes amongst other, which limit their …

Endogenous advanced glycation end products in the pathogenesis of chronic diabetic complications

MA Mengstie, E Chekol Abebe… - Frontiers in molecular …, 2022 - frontiersin.org
Diabetes is a common metabolic illness characterized by hyperglycemia and is linked to
long-term vascular problems that can impair the kidney, eyes, nerves, and blood vessels. By …

Advanced glycation end products (AGEs) may be a striking link between modern diet and health

V Gill, V Kumar, K Singh, A Kumar, JJ Kim - Biomolecules, 2019 - mdpi.com
The Maillard reaction is a simple but ubiquitous reaction that occurs both in vivo and ex vivo
during the cooking or processing of foods under high-temperature conditions, such as …

Tetrahedral framework nucleic acids based small interfering RNA targeting receptor for advanced glycation end products for diabetic complications treatment

Z Cai, Y Li, L Bai, J Xu, Z Liu, T Zhang, S Gao, Y Lin - ACS nano, 2023 - ACS Publications
Complications arising from diabetes can threaten multiple organs. Advanced glycation end
products (AGEs) play a significant role in inducing these complications. Highly processed …