Metabolic rewiring is considered as a primary feature of cancer. Malignant cells reprogram
metabolism pathway in response to various intrinsic and extrinsic drawback to fuel cell …

CAD (Carbamoyl-phosphate synthetase 2, Aspartate transcarbamoylase, and
Dihydroorotase) is a multifunctional protein that participates in the initial three speed-limiting …

Unexplained global developmental delay and epilepsy in childhood pose a major
socioeconomic burden. Progress in defining the molecular bases does not often translate …

CAD is a large, 2225 amino acid multienzymatic protein required for de novo pyrimidine
biosynthesis. Pathological CAD variants cause a developmental and epileptic …

CAD is a 1.5 MDa particle formed by hexameric association of a 250 kDa protein divided
into different enzymatic domains, each catalyzing one of the initial reactions for de novo …

Background Methylation plays an important role in the etiology and pathogenesis of
colorectal cancer (CRC). This study aimed to identify aberrantly methylated-differentially …

Dihydroorotase (DHOase) is the third enzyme in the de novo biosynthesis pathway for
pyrimidine nucleotides, and an attractive target for potential anticancer chemotherapy. By …

Foot-and-mouth disease virus (FMDV) is a single-stranded picornavirus that causes
economically devastating disease in even-hooved animals. There has been little research …

Background: Activated anaplastic lymphoma kinase (ALK) gene fusions are recurrent events
in a small fraction of colorectal cancers (CRCs), although these events have not yet been …

CAD, the multifunctional protein initiating and controlling de novo biosynthesis of
pyrimidines in animals, self-assembles into∼ 1.5 MDa hexamers. The structures of the …